| Sep 28, 2000 | 2Florida State 59, Maryland 7 | Box score |
| Sep 28, 2000 | West Virginia 29, Temple 24 | Box score |
| Sep 30, 2000 | Akron 37, Miami (OH) 20 | Box score |
| Sep 30, 2000 | Alabama 27, 23South Carolina 17upset | Box score |
| Sep 30, 2000 | UAB 47, Louisiana 2 | Box score |
| Sep 30, 2000 | Arizona 27, Stanford 3 | Box score |
| Sep 30, 2000 | 19Auburn 33, Vanderbilt 0 | Box score |
| Sep 30, 2000 | Bowling Green 18, Kent State 11 | Box score |
| Sep 30, 2000 | UCF 31, Eastern Michigan 10 | Box score |
| Sep 30, 2000 | 7Clemson 52, Duke 22 | Box score |
| Sep 30, 2000 | Colorado State 45, Nevada 14 | Box score |
| Sep 30, 2000 | 25Georgia 38, Arkansas 7 | Box score |
| Sep 30, 2000 | Georgia Tech 42, North Carolina 28 | Box score |
| Sep 30, 2000 | Houston 17, SMU 15 | Box score |
| Sep 30, 2000 | Indiana 45, Iowa 33 | Box score |
| Sep 30, 2000 | Iowa State 31, Baylor 17 | Box score |
| Sep 30, 2000 | 5Kansas State 44, Colorado 21 | Box score |
| Sep 30, 2000 | LSU 38, 11Tennessee 31upset | Box score |
| Sep 30, 2000 | Louisville 41, UConn 22 | Box score |
| Sep 30, 2000 | Marshall 47, Buffalo 14 | Box score |
| Sep 30, 2000 | 10Miami 64, Rutgers 6 | Box score |
| Sep 30, 2000 | 9Michigan 13, 17Wisconsin 10 | Box score |
| Sep 30, 2000 | Minnesota 44, 24Illinois 10upset | Box score |
| Sep 30, 2000 | Ole Miss 35, Kentucky 17 | Box score |
| Sep 30, 2000 | Mississippi State 47, 3Florida 35upset | Box score |
| Sep 30, 2000 | 1Nebraska 42, Missouri 24 | Box score |
| Sep 30, 2000 | UNLV 34, Air Force 13upset | Box score |
| Sep 30, 2000 | New Mexico 45, Wyoming 10 | Box score |
| Sep 30, 2000 | Northern Illinois 43, Ball State 14 | Box score |
| Sep 30, 2000 | Northwestern 37, 18Michigan State 17upset | Box score |
| Sep 30, 2000 | 14Oklahoma 34, Kansas 16 | Box score |
| Sep 30, 2000 | 20Oregon 23, 6Washington 16upset | Box score |
| Sep 30, 2000 | Oregon State 31, 8USC 21upset | Box score |
| Sep 30, 2000 | Penn State 22, 22Purdue 20upset | Box score |
| Sep 30, 2000 | San José State 29, Rice 16 | Box score |
| Sep 30, 2000 | 21Southern Miss 24, Memphis 3 | Box score |
| Sep 30, 2000 | Syracuse 42, BYU 14 | Box score |
| Sep 30, 2000 | 13Texas 42, Oklahoma State 7 | Box score |
| Sep 30, 2000 | Texas A&M 33, Texas Tech 15 | Box score |
| Sep 30, 2000 | 16TCU 24, Navy 0 | Box score |
| Sep 30, 2000 | UTEP 41, New Mexico State 31 | Box score |
| Sep 30, 2000 | Toledo 41, Central Michigan 0 | Box score |
| Sep 30, 2000 | Tulane 24, Cincinnati 19 | Box score |
| Sep 30, 2000 | Tulsa 24, Hawai’i 14 | Box score |
| Sep 30, 2000 | 15UCLA 38, Arizona State 31 | Box score |
| Sep 30, 2000 | Utah 35, Utah State 14 | Box score |
| Sep 30, 2000 | Virginia 27, Wake Forest 10 | Box score |
| Sep 30, 2000 | 4Virginia Tech 48, Boston College 34 | Box score |
| Sep 30, 2000 | Washington State 21, California 17 | Box score |
| Sep 30, 2000 | Western Michigan 23, Ohio 10 | Box score |