| Sep 21, 2000 | NC State 30, Georgia Tech 23 | Box score |
| Sep 23, 2000 | Air Force 23, Utah 14 | Box score |
| Sep 23, 2000 | Akron 23, Ohio 20 | Box score |
| Sep 23, 2000 | UAB 13, LSU 10 | Box score |
| Sep 23, 2000 | Arizona State 44, Utah State 20 | Box score |
| Sep 23, 2000 | Arkansas 28, Alabama 21 | Box score |
| Sep 23, 2000 | 20Auburn 31, Northern Illinois 14 | Box score |
| Sep 23, 2000 | Baylor 28, South Florida 13 | Box score |
| Sep 23, 2000 | Boise State 47, Central Michigan 10 | Box score |
| Sep 23, 2000 | Boston College 48, Navy 7 | Box score |
| Sep 23, 2000 | BYU 10, UNLV 7 | Box score |
| Sep 23, 2000 | Buffalo 20, Bowling Green 17upset | Box score |
| Sep 23, 2000 | 11Clemson 31, Virginia 10 | Box score |
| Sep 23, 2000 | East Carolina 34, Syracuse 17 | Box score |
| Sep 23, 2000 | 3Florida 59, Kentucky 31 | Box score |
| Sep 23, 2000 | 2Florida State 31, Louisville 0 | Box score |
| Sep 23, 2000 | Fresno State 17, California 3 | Box score |
| Sep 23, 2000 | 24Georgia 37, New Mexico State 0 | Box score |
| Sep 23, 2000 | Idaho 38, Washington State 34 | Box score |
| Sep 23, 2000 | Indiana 42, Cincinnati 6 | Box score |
| Sep 23, 2000 | 4Kansas State 55, North Texas 10 | Box score |
| Sep 23, 2000 | Maryland 45, Middle Tennessee 27 | Box score |
| Sep 23, 2000 | Memphis 26, Army 16 | Box score |
| Sep 23, 2000 | 12Miami 47, West Virginia 10 | Box score |
| Sep 23, 2000 | Miami (OH) 45, Kent State 14 | Box score |
| Sep 23, 2000 | 10Michigan 35, 19Illinois 31 | Box score |
| Sep 23, 2000 | 23Michigan State 27, 16Notre Dame 21upset | Box score |
| Sep 23, 2000 | 1Nebraska 42, Iowa 13 | Box score |
| Sep 23, 2000 | Nevada 35, Wyoming 28upset | Box score |
| Sep 23, 2000 | North Carolina 20, Marshall 15 | Box score |
| Sep 23, 2000 | Northwestern 47, 7Wisconsin 44upset | Box score |
| Sep 23, 2000 | 14Ohio State 45, Penn State 6 | Box score |
| Sep 23, 2000 | 17Oklahoma 42, Rice 14 | Box score |
| Sep 23, 2000 | Oregon 29, 6UCLA 10upset | Box score |
| Sep 23, 2000 | Oregon State 35, San Diego State 3 | Box score |
| Sep 23, 2000 | Pittsburgh 29, Rutgers 17 | Box score |
| Sep 23, 2000 | 21Purdue 38, Minnesota 24 | Box score |
| Sep 23, 2000 | South Carolina 23, 25Mississippi State 19upset | Box score |
| Sep 23, 2000 | 9USC 34, San José State 24 | Box score |
| Sep 23, 2000 | 22Southern Miss 28, Oklahoma State 6 | Box score |
| Sep 23, 2000 | Temple 49, Eastern Michigan 40 | Box score |
| Sep 23, 2000 | 13Tennessee 70, UL Monroe 3 | Box score |
| Sep 23, 2000 | 15Texas 48, Houston 0 | Box score |
| Sep 23, 2000 | 18TCU 52, Arkansas State 3 | Box score |
| Sep 23, 2000 | UTEP 39, Hawai’i 7 | Box score |
| Sep 23, 2000 | Tulane 29, SMU 17 | Box score |
| Sep 23, 2000 | Tulsa 22, Louisiana Tech 10 | Box score |
| Sep 23, 2000 | Vanderbilt 26, Duke 7 | Box score |
| Sep 23, 2000 | Western Michigan 21, Toledo 14 | Box score |