| Sep 14, 2000 | Mississippi State 44, BYU 28 | Box score |
| Sep 16, 2000 | Akron 35, UCF 24 | Box score |
| Sep 16, 2000 | Arizona 17, San Diego State 3 | Box score |
| Sep 16, 2000 | Arizona State 13, Colorado State 10 | Box score |
| Sep 16, 2000 | Arkansas 38, Boise State 31 | Box score |
| Sep 16, 2000 | 24Auburn 34, LSU 17 | Box score |
| Sep 16, 2000 | 16Clemson 55, Wake Forest 7 | Box score |
| Sep 16, 2000 | UConn 24, Buffalo 21 | Box score |
| Sep 16, 2000 | East Carolina 37, Tulane 17 | Box score |
| Sep 16, 2000 | 6Florida 27, 11Tennessee 23 | Box score |
| Sep 16, 2000 | 2Florida State 63, North Carolina 14 | Box score |
| Sep 16, 2000 | Georgia Tech 40, Navy 13 | Box score |
| Sep 16, 2000 | Houston 31, Army 30 | Box score |
| Sep 16, 2000 | 19Illinois 17, California 15 | Box score |
| Sep 16, 2000 | Iowa State 24, Iowa 14 | Box score |
| Sep 16, 2000 | Kansas 23, UAB 20 | Box score |
| Sep 16, 2000 | 7Kansas State 76, Ball State 0 | Box score |
| Sep 16, 2000 | Kentucky 41, Indiana 34 | Box score |
| Sep 16, 2000 | Memphis 19, Arkansas State 17 | Box score |
| Sep 16, 2000 | 22Michigan State 13, Missouri 10 | Box score |
| Sep 16, 2000 | Minnesota 34, Baylor 9 | Box score |
| Sep 16, 2000 | Ole Miss 12, Vanderbilt 7 | Box score |
| Sep 16, 2000 | UNLV 38, North Texas 0 | Box score |
| Sep 16, 2000 | New Mexico 16, New Mexico State 13 | Box score |
| Sep 16, 2000 | NC State 41, SMU 0 | Box score |
| Sep 16, 2000 | 21Notre Dame 23, 13Purdue 21upset | Box score |
| Sep 16, 2000 | 17Ohio State 27, Miami (OH) 16 | Box score |
| Sep 16, 2000 | Oregon 42, Idaho 13 | Box score |
| Sep 16, 2000 | Pittsburgh 12, Penn State 0 | Box score |
| Sep 16, 2000 | South Carolina 41, Eastern Michigan 6 | Box score |
| Sep 16, 2000 | 25Southern Miss 21, 15Alabama 0upset | Box score |
| Sep 16, 2000 | Stanford 27, 5Texas 24upset | Box score |
| Sep 16, 2000 | Temple 31, Bowling Green 14 | Box score |
| Sep 16, 2000 | Texas A&M 45, UTEP 17 | Box score |
| Sep 16, 2000 | 20TCU 41, Northwestern 14 | Box score |
| Sep 16, 2000 | Texas Tech 26, Louisiana 0 | Box score |
| Sep 16, 2000 | Tulsa 23, Rice 16upset | Box score |
| Sep 16, 2000 | 14UCLA 23, 3Michigan 20upset | Box score |
| Sep 16, 2000 | Virginia 26, Duke 10 | Box score |
| Sep 16, 2000 | 8Virginia Tech 49, Rutgers 0 | Box score |
| Sep 16, 2000 | 9Washington 17, Colorado 14 | Box score |
| Sep 16, 2000 | Washington State 38, Utah 21upset | Box score |
| Sep 16, 2000 | West Virginia 30, Maryland 17 | Box score |
| Sep 16, 2000 | 4Wisconsin 28, Cincinnati 25 | Box score |
| Sep 16, 2000 | Wyoming 31, Central Michigan 10 | Box score |