| Sep 7, 2000 | 10Virginia Tech 45, East Carolina 28 | Box score |
| Sep 9, 2000 | Air Force 31, BYU 23 | Box score |
| Sep 9, 2000 | 13Alabama 28, Vanderbilt 10 | Box score |
| Sep 9, 2000 | Auburn 35, 19Ole Miss 27upset | Box score |
| Sep 9, 2000 | Boston College 55, Army 17 | Box score |
| Sep 9, 2000 | California 24, Utah 21 | Box score |
| Sep 9, 2000 | Central Michigan 17, Akron 7 | Box score |
| Sep 9, 2000 | Cincinnati 12, Syracuse 10 | Box score |
| Sep 9, 2000 | 17Clemson 62, Missouri 9 | Box score |
| Sep 9, 2000 | 8Florida 55, Middle Tennessee 0 | Box score |
| Sep 9, 2000 | 2Florida State 26, Georgia Tech 21 | Box score |
| Sep 9, 2000 | 21Illinois 49, San Diego State 13 | Box score |
| Sep 9, 2000 | Iowa State 37, UNLV 22 | Box score |
| Sep 9, 2000 | Kentucky 27, South Florida 9 | Box score |
| Sep 9, 2000 | LSU 28, Houston 13 | Box score |
| Sep 9, 2000 | Maryland 17, Temple 10 | Box score |
| Sep 9, 2000 | Memphis 28, UL Monroe 0 | Box score |
| Sep 9, 2000 | Miami (OH) 34, Eastern Michigan 17 | Box score |
| Sep 9, 2000 | 3Michigan 38, Rice 7 | Box score |
| Sep 9, 2000 | 24Michigan State 34, Marshall 24 | Box score |
| Sep 9, 2000 | 1Nebraska 27, 23Notre Dame 24 | Box score |
| Sep 9, 2000 | North Carolina 35, Wake Forest 14 | Box score |
| Sep 9, 2000 | NC State 41, Indiana 38 | Box score |
| Sep 9, 2000 | Northwestern 38, Duke 5 | Box score |
| Sep 9, 2000 | Ohio 23, Minnesota 17upset | Box score |
| Sep 9, 2000 | 18Ohio State 27, Arizona 17 | Box score |
| Sep 9, 2000 | 20Oklahoma 45, Arkansas State 7 | Box score |
| Sep 9, 2000 | Oklahoma State 36, Tulsa 26 | Box score |
| Sep 9, 2000 | Oregon State 28, New Mexico 20 | Box score |
| Sep 9, 2000 | Penn State 67, Louisiana Tech 7 | Box score |
| Sep 9, 2000 | Pittsburgh 34, Bowling Green 16 | Box score |
| Sep 9, 2000 | 14Purdue 45, Kent State 10 | Box score |
| Sep 9, 2000 | Rutgers 59, Buffalo 0 | Box score |
| Sep 9, 2000 | San José State 40, Stanford 27upset | Box score |
| Sep 9, 2000 | South Carolina 21, 9Georgia 10upset | Box score |
| Sep 9, 2000 | 11USC 17, Colorado 14 | Box score |
| Sep 9, 2000 | 6Texas 52, Louisiana 10 | Box score |
| Sep 9, 2000 | Texas A&M 51, Wyoming 3 | Box score |
| Sep 9, 2000 | 22TCU 41, Nevada 10 | Box score |
| Sep 9, 2000 | Texas Tech 13, North Texas 7 | Box score |
| Sep 9, 2000 | UTEP 37, SMU 20 | Box score |
| Sep 9, 2000 | 16UCLA 24, Fresno State 21 | Box score |
| Sep 9, 2000 | 15Washington 34, 4Miami 29upset | Box score |
| Sep 9, 2000 | Western Michigan 27, Iowa 21 | Box score |
| Sep 9, 2000 | 5Wisconsin 27, Oregon 23 | Box score |