| Aug 31, 2000 | Arizona State 10, San Diego State 7 | Box score |
| Aug 31, 2000 | Auburn 35, Wyoming 21 | Box score |
| Aug 31, 2000 | Baylor 20, North Texas 7 | Box score |
| Aug 31, 2000 | Northwestern 35, Northern Illinois 17 | Box score |
| Aug 31, 2000 | 4Wisconsin 19, Western Michigan 7 | Box score |
| Sep 2, 2000 | Arizona 17, Utah 3 | Box score |
| Sep 2, 2000 | Boise State 31, New Mexico 14 | Box score |
| Sep 2, 2000 | BYU 38, Virginia 35 | Box score |
| Sep 2, 2000 | Colorado State 28, 23Colorado 24upset | Box score |
| Sep 2, 2000 | East Carolina 38, Duke 0 | Box score |
| Sep 2, 2000 | Eastern Michigan 32, UConn 25 | Box score |
| Sep 2, 2000 | 9Florida 40, Ball State 19 | Box score |
| Sep 2, 2000 | Georgia Tech 21, UCF 17 | Box score |
| Sep 2, 2000 | 21Illinois 35, Middle Tennessee 6 | Box score |
| Sep 2, 2000 | Iowa State 25, Ohio 15 | Box score |
| Sep 2, 2000 | 8Kansas State 54, Louisiana Tech 10 | Box score |
| Sep 2, 2000 | Louisville 40, Kentucky 34 | Box score |
| Sep 2, 2000 | Miami (OH) 33, Vanderbilt 30 | Box score |
| Sep 2, 2000 | 6Michigan 42, Bowling Green 7 | Box score |
| Sep 2, 2000 | Minnesota 47, UL Monroe 10 | Box score |
| Sep 2, 2000 | 18Ole Miss 49, Tulane 20 | Box score |
| Sep 2, 2000 | Mississippi State 17, Memphis 3 | Box score |
| Sep 2, 2000 | 1Nebraska 49, San José State 13 | Box score |
| Sep 2, 2000 | North Carolina 30, Tulsa 9 | Box score |
| Sep 2, 2000 | NC State 38, Arkansas State 31 | Box score |
| Sep 2, 2000 | Notre Dame 24, 25Texas A&M 10upset | Box score |
| Sep 2, 2000 | 16Ohio State 43, Fresno State 10 | Box score |
| Sep 2, 2000 | 19Oklahoma 55, UTEP 14 | Box score |
| Sep 2, 2000 | Oregon 36, Nevada 7 | Box score |
| Sep 2, 2000 | Pittsburgh 30, Kent State 7 | Box score |
| Sep 2, 2000 | 15Purdue 48, Central Michigan 0 | Box score |
| Sep 2, 2000 | Rice 30, Houston 27 | Box score |
| Sep 2, 2000 | South Carolina 31, New Mexico State 0 | Box score |
| Sep 2, 2000 | SMU 31, Kansas 17 | Box score |
| Sep 2, 2000 | Stanford 24, Washington State 10 | Box score |
| Sep 2, 2000 | Syracuse 63, Buffalo 7 | Box score |
| Sep 2, 2000 | Temple 17, Navy 6upset | Box score |
| Sep 2, 2000 | 13Tennessee 19, 22Southern Miss 16 | Box score |
| Sep 2, 2000 | Texas Tech 38, Utah State 16 | Box score |
| Sep 2, 2000 | Toledo 24, Penn State 6upset | Box score |
| Sep 2, 2000 | UCLA 35, 3Alabama 24upset | Box score |
| Sep 2, 2000 | 11Virginia Tech 52, Akron 23 | Box score |
| Sep 2, 2000 | 14Washington 44, Idaho 20 | Box score |
| Sep 2, 2000 | West Virginia 34, Boston College 14 | Box score |
| Sep 4, 2000 | Cincinnati 23, Army 17 | Box score |