2000: Week 1
Five games. One ranked team lost. One game matched two ranked teams. Winners are listed first; numbers before names are AP ranks going in.
The week in review
Ranked against ranked
| Aug 27, 2000 | 15USC 29, 22Penn State 5 | Box score |
FBS vs. FBS
| Aug 26, 2000 | 2Florida State 29, BYU 3 | Box score |
| Aug 26, 2000 | 8Kansas State 27, Iowa 7 | Box score |
| Aug 26, 2000 | Texas Tech 24, New Mexico 3 | Box score |
| Aug 27, 2000 | 15USC 29, 22Penn State 5 | Box score |
Everyone else
| Aug 26, 2000 | Louisiana Tech 63, Mississippi Valley State 10 | Box score |