| Oct 23, 1999 | Akron 35, Navy 29 | Box score |
| Oct 23, 1999 | Arizona State 33, Washington State 21 | Box score |
| Oct 23, 1999 | Arkansas State 14, North Texas 10upset | Box score |
| Oct 23, 1999 | Army 35, New Mexico State 18 | Box score |
| Oct 23, 1999 | Boise State 52, Nevada 17 | Box score |
| Oct 23, 1999 | 19BYU 29, UNLV 0 | Box score |
| Oct 23, 1999 | Colorado 16, Iowa State 12 | Box score |
| Oct 23, 1999 | Colorado State 24, Wyoming 13 | Box score |
| Oct 23, 1999 | 20East Carolina 52, Tulane 7 | Box score |
| Oct 23, 1999 | Eastern Michigan 20, Toledo 13upset | Box score |
| Oct 23, 1999 | 1Florida State 17, Clemson 14 | Box score |
| Oct 23, 1999 | Fresno State 24, UTEP 23 | Box score |
| Oct 23, 1999 | 14Georgia 49, Kentucky 34 | Box score |
| Oct 23, 1999 | Hawai’i 35, Tulsa 21 | Box score |
| Oct 23, 1999 | Idaho 31, Utah State 3 | Box score |
| Oct 23, 1999 | Illinois 35, 9Michigan 29upset | Box score |
| Oct 23, 1999 | Indiana 38, Iowa 31 | Box score |
| Oct 23, 1999 | Kansas 21, Missouri 0 | Box score |
| Oct 23, 1999 | 7Kansas State 44, Oklahoma State 21 | Box score |
| Oct 23, 1999 | Louisiana Tech 46, UCF 35 | Box score |
| Oct 23, 1999 | UL Monroe 31, Louisiana 7 | Box score |
| Oct 23, 1999 | Louisville 39, Houston 33 | Box score |
| Oct 23, 1999 | 15Marshall 59, Buffalo 3 | Box score |
| Oct 23, 1999 | Maryland 45, North Carolina 7 | Box score |
| Oct 23, 1999 | 23Miami 31, Boston College 28 | Box score |
| Oct 23, 1999 | 12Mississippi State 17, LSU 16 | Box score |
| Oct 23, 1999 | NC State 31, Duke 24 | Box score |
| Oct 23, 1999 | Northern Illinois 50, Kent State 7 | Box score |
| Oct 23, 1999 | Ohio 17, Bowling Green 14 | Box score |
| Oct 23, 1999 | 22Ohio State 20, 24Minnesota 17 | Box score |
| Oct 23, 1999 | Oklahoma 51, 13Texas A&M 6upset | Box score |
| Oct 23, 1999 | Oregon 44, Arizona 41 | Box score |
| Oct 23, 1999 | Oregon State 55, UCLA 7 | Box score |
| Oct 23, 1999 | 2Penn State 31, 16Purdue 25 | Box score |
| Oct 23, 1999 | Pittsburgh 38, Rutgers 15 | Box score |
| Oct 23, 1999 | Rice 42, TCU 21 | Box score |
| Oct 23, 1999 | 21Southern Miss 28, Cincinnati 20 | Box score |
| Oct 23, 1999 | Stanford 35, USC 31 | Box score |
| Oct 23, 1999 | 5Tennessee 21, 10Alabama 7 | Box score |
| Oct 23, 1999 | 18Texas 24, 3Nebraska 20upset | Box score |
| Oct 23, 1999 | Texas Tech 35, Baylor 7 | Box score |
| Oct 23, 1999 | Utah 38, San Diego State 16 | Box score |
| Oct 23, 1999 | Vanderbilt 11, South Carolina 10 | Box score |
| Oct 23, 1999 | Wake Forest 47, UAB 3 | Box score |
| Oct 23, 1999 | Washington 31, California 27 | Box score |
| Oct 23, 1999 | West Virginia 20, Temple 17 | Box score |
| Oct 23, 1999 | Western Michigan 28, Ball State 0 | Box score |
| Oct 23, 1999 | 17Wisconsin 40, 11Michigan State 10upset | Box score |