| Oct 28, 1999 | Colorado State 31, Utah 24 | Box score |
| Oct 30, 1999 | 14Alabama 35, 20Southern Miss 14 | Box score |
| Oct 30, 1999 | Arizona 33, UCLA 7 | Box score |
| Oct 30, 1999 | Arkansas 34, Auburn 10 | Box score |
| Oct 30, 1999 | Arkansas State 31, Louisiana 27 | Box score |
| Oct 30, 1999 | Boise State 33, Utah State 27 | Box score |
| Oct 30, 1999 | Boston College 24, Syracuse 23upset | Box score |
| Oct 30, 1999 | Bowling Green 31, Central Michigan 7 | Box score |
| Oct 30, 1999 | 16BYU 27, Air Force 20 | Box score |
| Oct 30, 1999 | California 17, USC 7 | Box score |
| Oct 30, 1999 | UCF 31, Eastern Michigan 6 | Box score |
| Oct 30, 1999 | Cincinnati 52, Miami (OH) 42upset | Box score |
| Oct 30, 1999 | Clemson 12, Wake Forest 3 | Box score |
| Oct 30, 1999 | Colorado 38, 24Oklahoma 24upset | Box score |
| Oct 30, 1999 | Duke 25, Maryland 22upset | Box score |
| Oct 30, 1999 | 17East Carolina 19, Houston 3 | Box score |
| Oct 30, 1999 | 5Florida 30, 10Georgia 14 | Box score |
| Oct 30, 1999 | 1Florida State 35, Virginia 10 | Box score |
| Oct 30, 1999 | Fresno State 28, Tulsa 14 | Box score |
| Oct 30, 1999 | 7Georgia Tech 48, NC State 21 | Box score |
| Oct 30, 1999 | 6Kansas State 48, Baylor 7 | Box score |
| Oct 30, 1999 | Kent State 41, Buffalo 20 | Box score |
| Oct 30, 1999 | Louisiana Tech 34, Toledo 17 | Box score |
| Oct 30, 1999 | UL Monroe 10, Middle Tennessee 0 | Box score |
| Oct 30, 1999 | Louisville 23, UAB 14 | Box score |
| Oct 30, 1999 | 13Marshall 41, Northern Illinois 9 | Box score |
| Oct 30, 1999 | Memphis 49, Tulane 7upset | Box score |
| Oct 30, 1999 | 23Miami 28, West Virginia 20 | Box score |
| Oct 30, 1999 | 15Michigan 34, Indiana 31 | Box score |
| Oct 30, 1999 | 25Ole Miss 42, LSU 23 | Box score |
| Oct 30, 1999 | Missouri 34, Texas Tech 7 | Box score |
| Oct 30, 1999 | 8Nebraska 24, Kansas 17 | Box score |
| Oct 30, 1999 | Nevada 41, North Texas 28 | Box score |
| Oct 30, 1999 | New Mexico 27, UNLV 6 | Box score |
| Oct 30, 1999 | New Mexico State 42, Idaho 14upset | Box score |
| Oct 30, 1999 | Notre Dame 28, Navy 24 | Box score |
| Oct 30, 1999 | Ohio 37, Ball State 25 | Box score |
| Oct 30, 1999 | 21Ohio State 41, Iowa 11 | Box score |
| Oct 30, 1999 | Oregon 20, Arizona State 17 | Box score |
| Oct 30, 1999 | Oregon State 27, Washington State 13 | Box score |
| Oct 30, 1999 | 2Penn State 27, Illinois 7 | Box score |
| Oct 30, 1999 | 18Purdue 33, Minnesota 28 | Box score |
| Oct 30, 1999 | SMU 27, Rice 2upset | Box score |
| Oct 30, 1999 | Temple 56, Rutgers 28 | Box score |
| Oct 30, 1999 | 4Tennessee 30, South Carolina 7 | Box score |
| Oct 30, 1999 | 12Texas 44, Iowa State 41 | Box score |
| Oct 30, 1999 | 22Texas A&M 21, Oklahoma State 3 | Box score |
| Oct 30, 1999 | TCU 34, Hawai’i 14 | Box score |
| Oct 30, 1999 | UTEP 42, San José State 26 | Box score |
| Oct 30, 1999 | 3Virginia Tech 30, Pittsburgh 17 | Box score |
| Oct 30, 1999 | Washington 35, Stanford 30 | Box score |
| Oct 30, 1999 | Western Michigan 24, Akron 10 | Box score |
| Oct 30, 1999 | 11Wisconsin 35, Northwestern 19 | Box score |