| Nov 4, 1999 | 8Mississippi State 23, Kentucky 22 | Box score |
| Nov 6, 1999 | Air Force 28, Army 0 | Box score |
| Nov 6, 1999 | 12Alabama 23, LSU 17 | Box score |
| Nov 6, 1999 | UAB 36, 18East Carolina 17upset | Box score |
| Nov 6, 1999 | Arizona State 26, USC 16 | Box score |
| Nov 6, 1999 | Auburn 28, UCF 10 | Box score |
| Nov 6, 1999 | Boise State 63, Arkansas State 10 | Box score |
| Nov 6, 1999 | 15BYU 30, San Diego State 7 | Box score |
| Nov 6, 1999 | Clemson 58, Duke 7 | Box score |
| Nov 6, 1999 | Colorado State 36, New Mexico 22 | Box score |
| Nov 6, 1999 | Eastern Michigan 31, Ball State 21 | Box score |
| Nov 6, 1999 | 5Florida 13, Vanderbilt 6 | Box score |
| Nov 6, 1999 | Fresno State 47, Rice 18 | Box score |
| Nov 6, 1999 | Hawai’i 62, San José State 41 | Box score |
| Nov 6, 1999 | Houston 36, Tulane 31 | Box score |
| Nov 6, 1999 | Idaho 42, Nevada 33 | Box score |
| Nov 6, 1999 | Illinois 40, Iowa 24 | Box score |
| Nov 6, 1999 | Kansas 45, Baylor 10 | Box score |
| Nov 6, 1999 | 6Kansas State 20, Colorado 14 | Box score |
| Nov 6, 1999 | Louisiana Tech 58, UL Monroe 17 | Box score |
| Nov 6, 1999 | Louisville 23, Cincinnati 13 | Box score |
| Nov 6, 1999 | 13Marshall 28, Kent State 16 | Box score |
| Nov 6, 1999 | 22Miami 33, Pittsburgh 3 | Box score |
| Nov 6, 1999 | Miami (OH) 32, Akron 23 | Box score |
| Nov 6, 1999 | 16Michigan 37, Northwestern 3 | Box score |
| Nov 6, 1999 | 19Michigan State 23, 20Ohio State 7 | Box score |
| Nov 6, 1999 | Minnesota 24, 2Penn State 23upset | Box score |
| Nov 6, 1999 | 23Ole Miss 38, Arkansas 16 | Box score |
| Nov 6, 1999 | Navy 34, Rutgers 7 | Box score |
| Nov 6, 1999 | 9Nebraska 37, 21Texas A&M 0 | Box score |
| Nov 6, 1999 | New Mexico State 14, Utah State 6 | Box score |
| Nov 6, 1999 | NC State 30, Maryland 17 | Box score |
| Nov 6, 1999 | Oklahoma 37, Missouri 0 | Box score |
| Nov 6, 1999 | Oregon 52, Washington State 10 | Box score |
| Nov 6, 1999 | Oregon State 17, California 7 | Box score |
| Nov 6, 1999 | 25Southern Miss 20, Memphis 5 | Box score |
| Nov 6, 1999 | Syracuse 27, Temple 10 | Box score |
| Nov 6, 1999 | 4Tennessee 38, 24Notre Dame 14 | Box score |
| Nov 6, 1999 | 11Texas 34, Oklahoma State 21 | Box score |
| Nov 6, 1999 | Texas Tech 28, Iowa State 16 | Box score |
| Nov 6, 1999 | Toledo 32, Central Michigan 13 | Box score |
| Nov 6, 1999 | Tulsa 43, UTEP 19upset | Box score |
| Nov 6, 1999 | Virginia 45, 7Georgia Tech 38upset | Box score |
| Nov 6, 1999 | 3Virginia Tech 22, West Virginia 20 | Box score |
| Nov 6, 1999 | Wake Forest 19, North Carolina 3 | Box score |
| Nov 6, 1999 | Washington 33, Arizona 25 | Box score |
| Nov 6, 1999 | 10Wisconsin 28, 17Purdue 21 | Box score |
| Nov 6, 1999 | Wyoming 43, Utah 29upset | Box score |