| Nov 11, 1999 | North Carolina 10, NC State 6upset | Box score |
| Nov 13, 1999 | Air Force 35, UNLV 16 | Box score |
| Nov 13, 1999 | Akron 37, Kent State 34 | Box score |
| Nov 13, 1999 | 11Alabama 19, 8Mississippi State 7upset | Box score |
| Nov 13, 1999 | Arkansas 28, 3Tennessee 24upset | Box score |
| Nov 13, 1999 | Arkansas State 44, Nevada 28 | Box score |
| Nov 13, 1999 | Auburn 38, 14Georgia 21upset | Box score |
| Nov 13, 1999 | Boise State 45, New Mexico State 26 | Box score |
| Nov 13, 1999 | Boston College 34, West Virginia 17 | Box score |
| Nov 13, 1999 | Bowling Green 35, Ball State 14 | Box score |
| Nov 13, 1999 | UCF 39, Middle Tennessee 14 | Box score |
| Nov 13, 1999 | Central Michigan 29, Eastern Michigan 26 | Box score |
| Nov 13, 1999 | Colorado 37, Baylor 0 | Box score |
| Nov 13, 1999 | Duke 48, Wake Forest 35 | Box score |
| Nov 13, 1999 | 24East Carolina 48, Cincinnati 34 | Box score |
| Nov 13, 1999 | 4Florida 20, South Carolina 3 | Box score |
| Nov 13, 1999 | 1Florida State 49, Maryland 10 | Box score |
| Nov 13, 1999 | 13Georgia Tech 45, Clemson 42 | Box score |
| Nov 13, 1999 | Hawai’i 31, Fresno State 24 | Box score |
| Nov 13, 1999 | Houston 20, LSU 7 | Box score |
| Nov 13, 1999 | Illinois 46, 25Ohio State 20upset | Box score |
| Nov 13, 1999 | Kentucky 19, Vanderbilt 17 | Box score |
| Nov 13, 1999 | Louisiana Tech 41, UAB 20 | Box score |
| Nov 13, 1999 | UL Monroe 37, Tulsa 34 | Box score |
| Nov 13, 1999 | 12Marshall 31, Western Michigan 17 | Box score |
| Nov 13, 1999 | Memphis 14, Army 10 | Box score |
| Nov 13, 1999 | 16Michigan 31, 6Penn State 27upset | Box score |
| Nov 13, 1999 | 17Michigan State 34, Northwestern 0 | Box score |
| Nov 13, 1999 | 20Minnesota 44, Indiana 20 | Box score |
| Nov 13, 1999 | Navy 45, Tulane 21 | Box score |
| Nov 13, 1999 | 7Nebraska 41, 5Kansas State 15upset | Box score |
| Nov 13, 1999 | Ohio 40, Miami (OH) 28 | Box score |
| Nov 13, 1999 | Oklahoma 31, Iowa State 10 | Box score |
| Nov 13, 1999 | Oklahoma State 45, Kansas 13 | Box score |
| Nov 13, 1999 | Oregon 24, California 19 | Box score |
| Nov 13, 1999 | Oregon State 28, Arizona 20 | Box score |
| Nov 13, 1999 | Pittsburgh 37, Notre Dame 27 | Box score |
| Nov 13, 1999 | Rutgers 24, Syracuse 21upset | Box score |
| Nov 13, 1999 | USC 31, Washington State 28 | Box score |
| Nov 13, 1999 | 21Southern Miss 48, Louisiana 0 | Box score |
| Nov 13, 1999 | Stanford 50, Arizona State 30 | Box score |
| Nov 13, 1999 | 10Texas 58, Texas Tech 7 | Box score |
| Nov 13, 1999 | Texas A&M 51, Missouri 14 | Box score |
| Nov 13, 1999 | TCU 27, North Texas 3 | Box score |
| Nov 13, 1999 | UTEP 30, Rice 29upset | Box score |
| Nov 13, 1999 | Toledo 44, Northern Illinois 14 | Box score |
| Nov 13, 1999 | UCLA 23, 23Washington 20upset | Box score |
| Nov 13, 1999 | Utah 52, New Mexico 7 | Box score |
| Nov 13, 1999 | Virginia 50, Buffalo 21 | Box score |
| Nov 13, 1999 | 2Virginia Tech 43, 19Miami 10 | Box score |
| Nov 13, 1999 | 9Wisconsin 41, Iowa 3 | Box score |
| Nov 13, 1999 | Wyoming 31, 15BYU 17upset | Box score |