| Nov 18, 1999 | Colorado State 41, Air Force 21 | Box score |
| Nov 20, 1999 | 8Alabama 28, Auburn 17 | Box score |
| Nov 20, 1999 | UAB 23, Tulane 20 | Box score |
| Nov 20, 1999 | 22Arkansas 14, 12Mississippi State 9upset | Box score |
| Nov 20, 1999 | Boise State 45, Idaho 14 | Box score |
| Nov 20, 1999 | 25Boston College 31, Notre Dame 29 | Box score |
| Nov 20, 1999 | Bowling Green 33, UCF 30upset | Box score |
| Nov 20, 1999 | Central Michigan 27, Ball State 21 | Box score |
| Nov 20, 1999 | Clemson 31, South Carolina 21 | Box score |
| Nov 20, 1999 | 23East Carolina 23, NC State 6 | Box score |
| Nov 20, 1999 | 1Florida State 30, 3Florida 23 | Box score |
| Nov 20, 1999 | Fresno State 63, San José State 12 | Box score |
| Nov 20, 1999 | 21Georgia 20, 16Ole Miss 17upset | Box score |
| Nov 20, 1999 | Hawai’i 48, Navy 41 | Box score |
| Nov 20, 1999 | Houston 26, Army 14 | Box score |
| Nov 20, 1999 | Illinois 29, Northwestern 7 | Box score |
| Nov 20, 1999 | Kansas 31, Iowa State 28 | Box score |
| Nov 20, 1999 | 9Kansas State 66, Missouri 0 | Box score |
| Nov 20, 1999 | Memphis 21, Cincinnati 13 | Box score |
| Nov 20, 1999 | Miami 55, Rutgers 0 | Box score |
| Nov 20, 1999 | Miami (OH) 43, Buffalo 0 | Box score |
| Nov 20, 1999 | 10Michigan 24, Ohio State 17 | Box score |
| Nov 20, 1999 | 15Michigan State 35, 13Penn State 28upset | Box score |
| Nov 20, 1999 | 17Minnesota 25, Iowa 21 | Box score |
| Nov 20, 1999 | New Mexico State 22, North Texas 9 | Box score |
| Nov 20, 1999 | North Carolina 38, Duke 0 | Box score |
| Nov 20, 1999 | Northern Illinois 30, Eastern Michigan 23 | Box score |
| Nov 20, 1999 | Oklahoma State 34, Baylor 14 | Box score |
| Nov 20, 1999 | Oregon 25, Oregon State 14 | Box score |
| Nov 20, 1999 | 19Purdue 30, Indiana 24 | Box score |
| Nov 20, 1999 | San Diego State 37, UNLV 7 | Box score |
| Nov 20, 1999 | USC 17, UCLA 7 | Box score |
| Nov 20, 1999 | SMU 28, Tulsa 14 | Box score |
| Nov 20, 1999 | 18Southern Miss 30, Louisville 27 | Box score |
| Nov 20, 1999 | Stanford 31, California 13 | Box score |
| Nov 20, 1999 | 7Tennessee 56, Kentucky 21 | Box score |
| Nov 20, 1999 | TCU 52, UTEP 24 | Box score |
| Nov 20, 1999 | Texas Tech 38, Oklahoma 28 | Box score |
| Nov 20, 1999 | Toledo 45, Western Michigan 21 | Box score |
| Nov 20, 1999 | Utah 20, 19BYU 17upset | Box score |
| Nov 20, 1999 | Utah State 37, Nevada 35 | Box score |
| Nov 20, 1999 | Virginia 34, Maryland 30 | Box score |
| Nov 20, 1999 | 2Virginia Tech 62, Temple 7 | Box score |
| Nov 20, 1999 | Wake Forest 26, 14Georgia Tech 23upset | Box score |
| Nov 20, 1999 | Washington 24, Washington State 14 | Box score |
| Nov 20, 1999 | Wyoming 42, New Mexico 28 | Box score |