| Oct 14, 1999 | 15Marshall 38, Toledo 13 | Box score |
| Oct 14, 1999 | SMU 24, Fresno State 14upset | Box score |
| Oct 16, 1999 | Akron 55, Bowling Green 25 | Box score |
| Oct 16, 1999 | 11Alabama 30, 22Ole Miss 24 | Box score |
| Oct 16, 1999 | UAB 24, Cincinnati 21 | Box score |
| Oct 16, 1999 | Arizona 34, UTEP 21 | Box score |
| Oct 16, 1999 | Arizona State 28, Washington 7upset | Box score |
| Oct 16, 1999 | Arkansas 48, South Carolina 14 | Box score |
| Oct 16, 1999 | Boston College 20, Pittsburgh 16 | Box score |
| Oct 16, 1999 | 21BYU 31, New Mexico 7 | Box score |
| Oct 16, 1999 | California 17, UCLA 0upset | Box score |
| Oct 16, 1999 | Clemson 42, Maryland 30 | Box score |
| Oct 16, 1999 | Eastern Michigan 27, Ohio 26 | Box score |
| Oct 16, 1999 | 7Florida 32, Auburn 14 | Box score |
| Oct 16, 1999 | 1Florida State 33, Wake Forest 10 | Box score |
| Oct 16, 1999 | 14Georgia 27, Vanderbilt 17 | Box score |
| Oct 16, 1999 | 8Georgia Tech 38, Duke 31 | Box score |
| Oct 16, 1999 | Houston 20, North Carolina 12upset | Box score |
| Oct 16, 1999 | Idaho 30, Arkansas State 24 | Box score |
| Oct 16, 1999 | Iowa State 24, Missouri 21upset | Box score |
| Oct 16, 1999 | 9Kansas State 40, Utah State 0 | Box score |
| Oct 16, 1999 | Kentucky 31, LSU 5 | Box score |
| Oct 16, 1999 | Louisiana Tech 42, Middle Tennessee 18 | Box score |
| Oct 16, 1999 | Louisville 32, Memphis 31 | Box score |
| Oct 16, 1999 | Miami (OH) 17, Kent State 10 | Box score |
| Oct 16, 1999 | Minnesota 37, Illinois 7 | Box score |
| Oct 16, 1999 | North Texas 17, Boise State 10 | Box score |
| Oct 16, 1999 | Northern Illinois 31, Central Michigan 27upset | Box score |
| Oct 16, 1999 | Northwestern 23, Iowa 21 | Box score |
| Oct 16, 1999 | Notre Dame 25, USC 24 | Box score |
| Oct 16, 1999 | 2Penn State 23, 18Ohio State 10 | Box score |
| Oct 16, 1999 | 20Purdue 52, 5Michigan State 28upset | Box score |
| Oct 16, 1999 | Rice 49, San José State 7 | Box score |
| Oct 16, 1999 | San Diego State 17, Colorado State 10upset | Box score |
| Oct 16, 1999 | 25Southern Miss 24, Army 0 | Box score |
| Oct 16, 1999 | Stanford 21, Oregon State 17 | Box score |
| Oct 16, 1999 | 13Texas A&M 34, Kansas 17 | Box score |
| Oct 16, 1999 | TCU 56, Tulsa 17 | Box score |
| Oct 16, 1999 | Texas Tech 31, Colorado 10 | Box score |
| Oct 16, 1999 | Tulane 48, Louisiana 32 | Box score |
| Oct 16, 1999 | Utah 21, Air Force 15upset | Box score |
| Oct 16, 1999 | Virginia 47, NC State 26 | Box score |
| Oct 16, 1999 | 4Virginia Tech 62, 16Syracuse 0 | Box score |
| Oct 16, 1999 | West Virginia 62, Rutgers 16 | Box score |
| Oct 16, 1999 | Western Michigan 45, Buffalo 17 | Box score |
| Oct 16, 1999 | 17Wisconsin 59, Indiana 0 | Box score |
| Oct 16, 1999 | Wyoming 38, UL Monroe 20 | Box score |