| Oct 7, 1999 | Army 59, Louisville 52 | Box score |
| Oct 7, 1999 | 18Syracuse 24, Pittsburgh 17 | Box score |
| Oct 9, 1999 | Air Force 19, Navy 14 | Box score |
| Oct 9, 1999 | Akron 41, Ohio 28 | Box score |
| Oct 9, 1999 | Arizona 31, 22USC 24upset | Box score |
| Oct 9, 1999 | Arkansas 58, Middle Tennessee 6 | Box score |
| Oct 9, 1999 | 24BYU 38, California 28 | Box score |
| Oct 9, 1999 | Central Michigan 38, Buffalo 19 | Box score |
| Oct 9, 1999 | Colorado 46, Missouri 39 | Box score |
| Oct 9, 1999 | Duke 24, Virginia 17upset | Box score |
| Oct 9, 1999 | 8Florida 31, LSU 10 | Box score |
| Oct 9, 1999 | 1Florida State 31, 19Miami 21 | Box score |
| Oct 9, 1999 | Fresno State 44, Colorado State 13 | Box score |
| Oct 9, 1999 | 7Georgia Tech 31, North Carolina 24 | Box score |
| Oct 9, 1999 | Houston 23, Cincinnati 20 | Box score |
| Oct 9, 1999 | Idaho 28, North Texas 10 | Box score |
| Oct 9, 1999 | Indiana 34, Northwestern 17 | Box score |
| Oct 9, 1999 | 9Kansas State 50, Kansas 9 | Box score |
| Oct 9, 1999 | Kentucky 30, South Carolina 10 | Box score |
| Oct 9, 1999 | Maryland 17, Wake Forest 14 | Box score |
| Oct 9, 1999 | Memphis 38, UAB 14upset | Box score |
| Oct 9, 1999 | Miami (OH) 45, Bowling Green 31 | Box score |
| Oct 9, 1999 | 11Michigan State 34, 3Michigan 31upset | Box score |
| Oct 9, 1999 | Ole Miss 20, Tulane 13 | Box score |
| Oct 9, 1999 | 14Mississippi State 18, Auburn 16 | Box score |
| Oct 9, 1999 | 4Nebraska 49, Iowa State 14 | Box score |
| Oct 9, 1999 | Nevada 23, New Mexico State 16 | Box score |
| Oct 9, 1999 | UNLV 35, Wyoming 32upset | Box score |
| Oct 9, 1999 | New Mexico 24, San Diego State 21upset | Box score |
| Oct 9, 1999 | NC State 35, Clemson 31 | Box score |
| Oct 9, 1999 | Northern Illinois 37, Ball State 17 | Box score |
| Oct 9, 1999 | Notre Dame 48, Arizona State 17 | Box score |
| Oct 9, 1999 | 21Ohio State 25, 17Purdue 22upset | Box score |
| Oct 9, 1999 | Oklahoma State 41, Texas Tech 21 | Box score |
| Oct 9, 1999 | 2Penn State 31, Iowa 7 | Box score |
| Oct 9, 1999 | Rice 38, Hawai’i 19 | Box score |
| Oct 9, 1999 | Southern Miss 39, 16East Carolina 22upset | Box score |
| Oct 9, 1999 | Temple 24, Boston College 14upset | Box score |
| Oct 9, 1999 | 6Tennessee 37, 10Georgia 20 | Box score |
| Oct 9, 1999 | 23Texas 38, Oklahoma 28 | Box score |
| Oct 9, 1999 | 13Texas A&M 45, Baylor 13 | Box score |
| Oct 9, 1999 | TCU 42, San José State 0 | Box score |
| Oct 9, 1999 | UTEP 42, SMU 28 | Box score |
| Oct 9, 1999 | Toledo 47, Kent State 7 | Box score |
| Oct 9, 1999 | UCLA 34, Oregon 29 | Box score |
| Oct 9, 1999 | Utah 42, UL Monroe 0 | Box score |
| Oct 9, 1999 | Utah State 20, Arkansas State 14 | Box score |
| Oct 9, 1999 | 5Virginia Tech 58, Rutgers 20 | Box score |
| Oct 9, 1999 | Washington 47, Oregon State 21 | Box score |
| Oct 9, 1999 | Washington State 44, Louisiana 0 | Box score |
| Oct 9, 1999 | Western Michigan 40, Eastern Michigan 37 | Box score |
| Oct 9, 1999 | 20Wisconsin 20, 25Minnesota 17 | Box score |