| Sep 30, 1999 | 9Georgia Tech 49, Maryland 31 | Box score |
| Oct 1, 1999 | BYU 34, Utah State 31 | Box score |
| Oct 2, 1999 | Air Force 23, San Diego State 22 | Box score |
| Oct 2, 1999 | Akron 31, Ball State 9 | Box score |
| Oct 2, 1999 | 21Alabama 40, 3Florida 39upset | Box score |
| Oct 2, 1999 | UAB 47, UL Monroe 0 | Box score |
| Oct 2, 1999 | Arizona State 28, UCLA 27 | Box score |
| Oct 2, 1999 | Baylor 23, North Texas 10 | Box score |
| Oct 2, 1999 | Boise State 26, Utah 20upset | Box score |
| Oct 2, 1999 | Bowling Green 34, Toledo 23 | Box score |
| Oct 2, 1999 | Clemson 31, North Carolina 20 | Box score |
| Oct 2, 1999 | Colorado State 46, New Mexico State 7 | Box score |
| Oct 2, 1999 | 19East Carolina 33, Army 14 | Box score |
| Oct 2, 1999 | 1Florida State 51, Duke 23 | Box score |
| Oct 2, 1999 | Fresno State 26, TCU 19 | Box score |
| Oct 2, 1999 | 10Georgia 23, LSU 22 | Box score |
| Oct 2, 1999 | Hawai’i 33, UTEP 3 | Box score |
| Oct 2, 1999 | Indiana 34, Illinois 31 | Box score |
| Oct 2, 1999 | Kansas 27, SMU 9 | Box score |
| Oct 2, 1999 | 13Kansas State 35, 15Texas 17 | Box score |
| Oct 2, 1999 | Kentucky 31, 20Arkansas 20upset | Box score |
| Oct 2, 1999 | Louisiana Tech 41, Louisiana 31 | Box score |
| Oct 2, 1999 | Louisville 45, Eastern Michigan 10 | Box score |
| Oct 2, 1999 | 17Marshall 32, Miami (OH) 14 | Box score |
| Oct 2, 1999 | 4Michigan 38, 11Purdue 12 | Box score |
| Oct 2, 1999 | 14Michigan State 49, Iowa 3 | Box score |
| Oct 2, 1999 | Minnesota 33, Northwestern 14 | Box score |
| Oct 2, 1999 | Ole Miss 36, South Carolina 10 | Box score |
| Oct 2, 1999 | 16Mississippi State 42, Vanderbilt 14 | Box score |
| Oct 2, 1999 | Missouri 27, Memphis 17 | Box score |
| Oct 2, 1999 | Navy 31, West Virginia 28upset | Box score |
| Oct 2, 1999 | 6Nebraska 38, Oklahoma State 14 | Box score |
| Oct 2, 1999 | Nevada 26, UNLV 12 | Box score |
| Oct 2, 1999 | Northern Illinois 45, Buffalo 21 | Box score |
| Oct 2, 1999 | Notre Dame 34, 23Oklahoma 30upset | Box score |
| Oct 2, 1999 | Ohio 31, Kent State 3 | Box score |
| Oct 2, 1999 | Pittsburgh 55, Temple 24 | Box score |
| Oct 2, 1999 | Rice 20, Tulsa 10 | Box score |
| Oct 2, 1999 | San José State 44, Stanford 39upset | Box score |
| Oct 2, 1999 | USC 37, Oregon State 29 | Box score |
| Oct 2, 1999 | 22Syracuse 47, Tulane 17 | Box score |
| Oct 2, 1999 | 7Tennessee 24, Auburn 0 | Box score |
| Oct 2, 1999 | Texas Tech 21, 5Texas A&M 19upset | Box score |
| Oct 2, 1999 | 8Virginia Tech 31, 24Virginia 7 | Box score |
| Oct 2, 1999 | Wake Forest 17, Rutgers 10 | Box score |
| Oct 2, 1999 | Washington 34, 25Oregon 20upset | Box score |
| Oct 2, 1999 | Washington State 31, California 7 | Box score |
| Oct 2, 1999 | Western Michigan 38, Central Michigan 16 | Box score |
| Oct 2, 1999 | Wisconsin 42, 12Ohio State 17upset | Box score |
| Oct 2, 1999 | Wyoming 28, Idaho 13 | Box score |