| Sep 23, 1999 | 8Virginia Tech 31, Clemson 11 | Box score |
| Sep 25, 1999 | Alabama 35, 14Arkansas 28upset | Box score |
| Sep 25, 1999 | UAB 29, Houston 10 | Box score |
| Sep 25, 1999 | Arizona 30, Washington State 24 | Box score |
| Sep 25, 1999 | Army 41, Ball State 21 | Box score |
| Sep 25, 1999 | Boise State 20, New Mexico 9 | Box score |
| Sep 25, 1999 | Boston College 27, Rutgers 7 | Box score |
| Sep 25, 1999 | California 24, Arizona State 23 | Box score |
| Sep 25, 1999 | East Carolina 27, 9Miami 23upset | Box score |
| Sep 25, 1999 | Eastern Michigan 38, Akron 17 | Box score |
| Sep 25, 1999 | 3Florida 38, Kentucky 10 | Box score |
| Sep 25, 1999 | 1Florida State 42, North Carolina 10 | Box score |
| Sep 25, 1999 | Fresno State 49, Nevada 24 | Box score |
| Sep 25, 1999 | 11Georgia 24, UCF 23 | Box score |
| Sep 25, 1999 | Hawai’i 20, SMU 0upset | Box score |
| Sep 25, 1999 | 15Kansas State 35, Iowa State 28 | Box score |
| Sep 25, 1999 | Kent State 41, Bowling Green 27upset | Box score |
| Sep 25, 1999 | Louisiana 45, Middle Tennessee 31 | Box score |
| Sep 25, 1999 | 21Marshall 34, Temple 0 | Box score |
| Sep 25, 1999 | Miami (OH) 24, Central Michigan 16 | Box score |
| Sep 25, 1999 | 4Michigan 21, 20Wisconsin 16 | Box score |
| Sep 25, 1999 | 19Michigan State 27, Illinois 10 | Box score |
| Sep 25, 1999 | Ole Miss 24, Auburn 17 | Box score |
| Sep 25, 1999 | 23Mississippi State 17, South Carolina 0 | Box score |
| Sep 25, 1999 | 6Nebraska 40, Missouri 10 | Box score |
| Sep 25, 1999 | Ohio 45, Buffalo 6 | Box score |
| Sep 25, 1999 | 12Ohio State 34, Cincinnati 20 | Box score |
| Sep 25, 1999 | Oklahoma 42, Louisville 21 | Box score |
| Sep 25, 1999 | Oregon 33, 16USC 30upset | Box score |
| Sep 25, 1999 | 2Penn State 45, Indiana 24 | Box score |
| Sep 25, 1999 | 13Purdue 31, Northwestern 23 | Box score |
| Sep 25, 1999 | Rice 20, Navy 17 | Box score |
| Sep 25, 1999 | San Diego State 41, Kansas 13 | Box score |
| Sep 25, 1999 | San José State 34, Tulsa 10 | Box score |
| Sep 25, 1999 | Stanford 42, 18UCLA 32upset | Box score |
| Sep 25, 1999 | Syracuse 30, West Virginia 7 | Box score |
| Sep 25, 1999 | 7Tennessee 17, Memphis 16 | Box score |
| Sep 25, 1999 | 22Texas 62, Baylor 0 | Box score |
| Sep 25, 1999 | 5Texas A&M 23, Southern Miss 6 | Box score |
| Sep 25, 1999 | TCU 24, Arkansas State 21 | Box score |
| Sep 25, 1999 | UTEP 54, New Mexico State 23 | Box score |
| Sep 25, 1999 | Utah 52, UNLV 14 | Box score |
| Sep 25, 1999 | Vanderbilt 31, Duke 14 | Box score |
| Sep 25, 1999 | Virginia 45, 17BYU 40upset | Box score |
| Sep 25, 1999 | Wake Forest 31, 25NC State 7upset | Box score |
| Sep 25, 1999 | Washington 31, Colorado 24 | Box score |
| Sep 25, 1999 | Western Michigan 24, Northern Illinois 21 | Box score |
| Sep 25, 1999 | Wyoming 10, 24Air Force 7upset | Box score |