| Sep 16, 1999 | 25BYU 34, 23Colorado State 13upset | Box score |
| Sep 18, 1999 | Air Force 31, Washington 21 | Box score |
| Sep 18, 1999 | Akron 25, Temple 15 | Box score |
| Sep 18, 1999 | 15Arkansas 44, UL Monroe 6 | Box score |
| Sep 18, 1999 | Auburn 41, LSU 7 | Box score |
| Sep 18, 1999 | Boston College 14, Navy 10 | Box score |
| Sep 18, 1999 | Cincinnati 17, 9Wisconsin 12upset | Box score |
| Sep 18, 1999 | Colorado 51, Kansas 17 | Box score |
| Sep 18, 1999 | East Carolina 21, South Carolina 3 | Box score |
| Sep 18, 1999 | 4Florida 23, 2Tennessee 21upset | Box score |
| Sep 18, 1999 | 1Florida State 42, 20NC State 11 | Box score |
| Sep 18, 1999 | 12Georgia Tech 41, UCF 10 | Box score |
| Sep 18, 1999 | Hawai’i 34, Boise State 19 | Box score |
| Sep 18, 1999 | Houston 45, Louisiana 0 | Box score |
| Sep 18, 1999 | Idaho 28, Washington State 17 | Box score |
| Sep 18, 1999 | Illinois 41, Louisville 36upset | Box score |
| Sep 18, 1999 | Iowa 24, Northern Illinois 0 | Box score |
| Sep 18, 1999 | Iowa State 24, UNLV 0 | Box score |
| Sep 18, 1999 | 16Kansas State 40, UTEP 7 | Box score |
| Sep 18, 1999 | Kentucky 44, Indiana 35 | Box score |
| Sep 18, 1999 | Louisiana Tech 29, 18Alabama 28upset | Box score |
| Sep 18, 1999 | Marshall 35, Bowling Green 16 | Box score |
| Sep 18, 1999 | Maryland 33, West Virginia 0 | Box score |
| Sep 18, 1999 | Memphis 31, Arkansas State 26 | Box score |
| Sep 18, 1999 | Miami (OH) 35, Eastern Michigan 14 | Box score |
| Sep 18, 1999 | 6Michigan 18, Syracuse 13 | Box score |
| Sep 18, 1999 | Michigan State 23, 24Notre Dame 13upset | Box score |
| Sep 18, 1999 | Mississippi State 29, Oklahoma State 11 | Box score |
| Sep 18, 1999 | Missouri 48, Western Michigan 34 | Box score |
| Sep 18, 1999 | 4Nebraska 20, Southern Miss 13 | Box score |
| Sep 18, 1999 | New Mexico State 35, 22Arizona State 7upset | Box score |
| Sep 18, 1999 | North Texas 21, Texas Tech 14upset | Box score |
| Sep 18, 1999 | Northwestern 15, Duke 12 | Box score |
| Sep 18, 1999 | 13Ohio State 40, Ohio 16 | Box score |
| Sep 18, 1999 | Oklahoma 41, Baylor 10 | Box score |
| Sep 18, 1999 | Oregon 72, Nevada 10 | Box score |
| Sep 18, 1999 | 3Penn State 27, 8Miami 23 | Box score |
| Sep 18, 1999 | Pittsburgh 30, Kent State 23 | Box score |
| Sep 18, 1999 | 14Purdue 58, Central Michigan 16 | Box score |
| Sep 18, 1999 | 17USC 24, San Diego State 21 | Box score |
| Sep 18, 1999 | Stanford 50, 19Arizona 22upset | Box score |
| Sep 18, 1999 | Texas 18, Rice 13 | Box score |
| Sep 18, 1999 | 7Texas A&M 62, Tulsa 13 | Box score |
| Sep 18, 1999 | Toledo 23, Ball State 10 | Box score |
| Sep 18, 1999 | Tulane 48, Army 28 | Box score |
| Sep 18, 1999 | 21UCLA 35, Fresno State 21 | Box score |
| Sep 18, 1999 | Utah 38, Utah State 18 | Box score |
| Sep 18, 1999 | Vanderbilt 37, Ole Miss 34upset | Box score |
| Sep 18, 1999 | Virginia 35, Wake Forest 7 | Box score |