| Sep 9, 1999 | BYU 35, Washington 28 | Box score |
| Sep 11, 1999 | Akron 17, Buffalo 10 | Box score |
| Sep 11, 1999 | 21Alabama 37, Houston 10 | Box score |
| Sep 11, 1999 | 19Arizona 34, Middle Tennessee 19 | Box score |
| Sep 11, 1999 | Auburn 30, Idaho 23 | Box score |
| Sep 11, 1999 | Clemson 33, 22Virginia 14upset | Box score |
| Sep 11, 1999 | Colorado 63, San José State 35 | Box score |
| Sep 11, 1999 | 24Colorado State 38, Nevada 33 | Box score |
| Sep 11, 1999 | East Carolina 27, Duke 9 | Box score |
| Sep 11, 1999 | 4Florida 58, UCF 27 | Box score |
| Sep 11, 1999 | 1Florida State 41, 10Georgia Tech 35 | Box score |
| Sep 11, 1999 | 12Georgia 24, South Carolina 9 | Box score |
| Sep 11, 1999 | Illinois 38, San Diego State 10 | Box score |
| Sep 11, 1999 | Iowa State 17, Iowa 10 | Box score |
| Sep 11, 1999 | 17Kansas State 40, Temple 0 | Box score |
| Sep 11, 1999 | LSU 52, North Texas 0 | Box score |
| Sep 11, 1999 | 6Michigan 37, Rice 3 | Box score |
| Sep 11, 1999 | Michigan State 51, Eastern Michigan 7 | Box score |
| Sep 11, 1999 | Minnesota 35, UL Monroe 0 | Box score |
| Sep 11, 1999 | Ole Miss 38, Arkansas State 14 | Box score |
| Sep 11, 1999 | Mississippi State 13, Memphis 10 | Box score |
| Sep 11, 1999 | Navy 48, Kent State 28 | Box score |
| Sep 11, 1999 | 5Nebraska 45, California 0 | Box score |
| Sep 11, 1999 | UNLV 27, Baylor 24 | Box score |
| Sep 11, 1999 | New Mexico State 35, New Mexico 28 | Box score |
| Sep 11, 1999 | North Carolina 42, Indiana 30 | Box score |
| Sep 11, 1999 | Northwestern 17, TCU 7 | Box score |
| Sep 11, 1999 | 13Ohio State 42, 14UCLA 20 | Box score |
| Sep 11, 1999 | Oklahoma State 46, Tulsa 9 | Box score |
| Sep 11, 1999 | Oregon 47, UTEP 28 | Box score |
| Sep 11, 1999 | Oregon State 46, Fresno State 23 | Box score |
| Sep 11, 1999 | 2Penn State 20, Pittsburgh 17 | Box score |
| Sep 11, 1999 | 20Purdue 28, 16Notre Dame 23upset | Box score |
| Sep 11, 1999 | Stanford 54, Washington State 17 | Box score |
| Sep 11, 1999 | Syracuse 47, Central Michigan 7 | Box score |
| Sep 11, 1999 | Texas 38, Rutgers 21 | Box score |
| Sep 11, 1999 | Texas Tech 38, Louisiana 17 | Box score |
| Sep 11, 1999 | Tulane 53, SMU 19 | Box score |
| Sep 11, 1999 | Vanderbilt 34, Northern Illinois 31 | Box score |
| Sep 11, 1999 | 11Virginia Tech 31, UAB 10 | Box score |
| Sep 11, 1999 | Wake Forest 34, Army 15 | Box score |
| Sep 11, 1999 | West Virginia 43, Miami (OH) 27 | Box score |
| Sep 11, 1999 | 9Wisconsin 50, Ball State 10 | Box score |