| Sep 2, 1999 | Maryland 6, Temple 0 | Box score |
| Sep 2, 1999 | Michigan State 27, Oregon 20 | Box score |
| Sep 2, 1999 | UNLV 26, North Texas 3upset | Box score |
| Sep 2, 1999 | Syracuse 35, Toledo 12 | Box score |
| Sep 4, 1999 | 20Alabama 28, Vanderbilt 17 | Box score |
| Sep 4, 1999 | 18Arkansas 26, SMU 0 | Box score |
| Sep 4, 1999 | Boston College 30, Baylor 29 | Box score |
| Sep 4, 1999 | California 21, Rutgers 7 | Box score |
| Sep 4, 1999 | Cincinnati 41, Kent State 3 | Box score |
| Sep 4, 1999 | Colorado State 41, 14Colorado 14upset | Box score |
| Sep 4, 1999 | East Carolina 30, West Virginia 23 | Box score |
| Sep 4, 1999 | 4Florida 55, Western Michigan 26 | Box score |
| Sep 4, 1999 | 12Georgia 38, Utah State 7 | Box score |
| Sep 4, 1999 | 10Georgia Tech 49, Navy 14 | Box score |
| Sep 4, 1999 | Houston 28, Rice 3 | Box score |
| Sep 4, 1999 | Illinois 41, Arkansas State 3 | Box score |
| Sep 4, 1999 | Indiana 21, Ball State 9 | Box score |
| Sep 4, 1999 | LSU 29, San José State 21 | Box score |
| Sep 4, 1999 | Louisville 56, Kentucky 28 | Box score |
| Sep 4, 1999 | Marshall 13, Clemson 10 | Box score |
| Sep 4, 1999 | Miami (OH) 28, Northwestern 3 | Box score |
| Sep 4, 1999 | 7Michigan 26, 16Notre Dame 22 | Box score |
| Sep 4, 1999 | Minnesota 33, Ohio 7 | Box score |
| Sep 4, 1999 | Ole Miss 3, Memphis 0 | Box score |
| Sep 4, 1999 | Mississippi State 40, Middle Tennessee 7 | Box score |
| Sep 4, 1999 | Missouri 31, UAB 28 | Box score |
| Sep 4, 1999 | 5Nebraska 42, Iowa 7 | Box score |
| Sep 4, 1999 | 24NC State 10, South Carolina 0 | Box score |
| Sep 4, 1999 | Oklahoma State 24, Louisiana 7 | Box score |
| Sep 4, 1999 | Oregon State 28, Nevada 13 | Box score |
| Sep 4, 1999 | 2Penn State 70, Akron 24 | Box score |
| Sep 4, 1999 | Pittsburgh 30, Bowling Green 10 | Box score |
| Sep 4, 1999 | 22Purdue 47, UCF 13 | Box score |
| Sep 4, 1999 | 21USC 62, Hawai’i 7 | Box score |
| Sep 4, 1999 | 3Tennessee 42, Wyoming 17 | Box score |
| Sep 4, 1999 | Texas 69, Stanford 17 | Box score |
| Sep 4, 1999 | 6Texas A&M 37, Louisiana Tech 17 | Box score |
| Sep 4, 1999 | UTEP 13, New Mexico 10 | Box score |
| Sep 4, 1999 | 17UCLA 38, Boise State 7 | Box score |
| Sep 4, 1999 | Utah 27, Washington State 7 | Box score |
| Sep 4, 1999 | 23Virginia 20, North Carolina 17 | Box score |
| Sep 5, 1999 | 15Arizona 35, TCU 31 | Box score |
| Sep 6, 1999 | 25Arizona State 31, Texas Tech 13 | Box score |
| Sep 6, 1999 | Southern Miss 48, Tulane 14 | Box score |