| Oct 25, 1991 | 4Michigan 52, Minnesota 6 | Box score |
| Oct 26, 1991 | Air Force 20, UTEP 13 | Box score |
| Oct 26, 1991 | Akron 17, Northern Illinois 7 | Box score |
| Oct 26, 1991 | 22Baylor 26, TCU 9 | Box score |
| Oct 26, 1991 | Boston College 28, Army 17 | Box score |
| Oct 26, 1991 | Bowling Green 23, Western Michigan 10 | Box score |
| Oct 26, 1991 | BYU 41, New Mexico 23 | Box score |
| Oct 26, 1991 | 10California 41, San José State 20 | Box score |
| Oct 26, 1991 | Central Michigan 10, Ball State 3 | Box score |
| Oct 26, 1991 | Cincinnati 17, Southern Miss 7upset | Box score |
| Oct 26, 1991 | 19Clemson 29, 12NC State 19upset | Box score |
| Oct 26, 1991 | 16Colorado 10, Kansas State 0 | Box score |
| Oct 26, 1991 | Duke 17, Maryland 13 | Box score |
| Oct 26, 1991 | 20East Carolina 24, 23Pittsburgh 23 | Box score |
| Oct 26, 1991 | 1Florida State 27, LSU 16 | Box score |
| Oct 26, 1991 | Fresno State 48, UNLV 22 | Box score |
| Oct 26, 1991 | 24Georgia 49, Kentucky 27 | Box score |
| Oct 26, 1991 | Georgia Tech 35, North Carolina 14 | Box score |
| Oct 26, 1991 | Indiana 28, Wisconsin 20 | Box score |
| Oct 26, 1991 | 11Iowa 31, Purdue 21 | Box score |
| Oct 26, 1991 | Long Beach State 7, Utah State 6 | Box score |
| Oct 26, 1991 | Louisiana 14, Louisiana Tech 14 | Box score |
| Oct 26, 1991 | 2Miami 36, Arizona 9 | Box score |
| Oct 26, 1991 | Mississippi State 24, Auburn 17upset | Box score |
| Oct 26, 1991 | 9Nebraska 63, Missouri 6 | Box score |
| Oct 26, 1991 | Northwestern 17, 17Illinois 11upset | Box score |
| Oct 26, 1991 | 5Notre Dame 24, USC 20 | Box score |
| Oct 26, 1991 | Ohio 45, Kent State 40 | Box score |
| Oct 26, 1991 | 14Ohio State 27, Michigan State 17 | Box score |
| Oct 26, 1991 | 21Oklahoma 41, Kansas 3 | Box score |
| Oct 26, 1991 | Iowa State 6, Oklahoma State 6 | Box score |
| Oct 26, 1991 | Pacific 27, New Mexico State 20 | Box score |
| Oct 26, 1991 | 8Penn State 51, West Virginia 6 | Box score |
| Oct 26, 1991 | San Diego State 24, Utah 21 | Box score |
| Oct 26, 1991 | Stanford 40, Oregon State 10 | Box score |
| Oct 26, 1991 | 18Syracuse 21, Rutgers 7 | Box score |
| Oct 26, 1991 | Texas 34, SMU 0 | Box score |
| Oct 26, 1991 | 13Texas A&M 27, Houston 18 | Box score |
| Oct 26, 1991 | Texas Tech 40, Rice 20 | Box score |
| Oct 26, 1991 | Toledo 24, Miami (OH) 7 | Box score |
| Oct 26, 1991 | Tulsa 33, Memphis 28 | Box score |
| Oct 26, 1991 | UCLA 21, Arizona State 16 | Box score |
| Oct 26, 1991 | Vanderbilt 30, Ole Miss 27upset | Box score |
| Oct 26, 1991 | Virginia 48, Wake Forest 7 | Box score |
| Oct 26, 1991 | Virginia Tech 41, Louisville 13 | Box score |
| Oct 26, 1991 | 3Washington 29, Oregon 7 | Box score |
| Oct 26, 1991 | Wyoming 35, Colorado State 28 | Box score |