| Oct 31, 1991 | BYU 40, Colorado State 17 | Box score |
| Nov 2, 1991 | 7Alabama 13, Mississippi State 7 | Box score |
| Nov 2, 1991 | Arizona 45, Oregon State 21 | Box score |
| Nov 2, 1991 | Ball State 10, Ohio 6 | Box score |
| Nov 2, 1991 | 21Baylor 9, 24Arkansas 5 | Box score |
| Nov 2, 1991 | Boston College 38, Pittsburgh 12 | Box score |
| Nov 2, 1991 | Bowling Green 17, Miami (OH) 7 | Box score |
| Nov 2, 1991 | 10California 52, USC 30 | Box score |
| Nov 2, 1991 | Eastern Michigan 14, Central Michigan 14 | Box score |
| Nov 2, 1991 | 16Clemson 28, Wake Forest 10 | Box score |
| Nov 2, 1991 | 17East Carolina 38, Tulane 28 | Box score |
| Nov 2, 1991 | 6Florida 31, Auburn 10 | Box score |
| Nov 2, 1991 | 1Florida State 40, Louisville 15 | Box score |
| Nov 2, 1991 | Georgia Tech 17, Duke 6 | Box score |
| Nov 2, 1991 | Hawai’i 52, Utah 26 | Box score |
| Nov 2, 1991 | Illinois 22, Wisconsin 6 | Box score |
| Nov 2, 1991 | Indiana 34, Minnesota 8 | Box score |
| Nov 2, 1991 | 11Iowa 16, 13Ohio State 9 | Box score |
| Nov 2, 1991 | Iowa State 23, Missouri 22upset | Box score |
| Nov 2, 1991 | Kansas 31, Oklahoma State 0 | Box score |
| Nov 2, 1991 | Kent State 14, Toledo 13upset | Box score |
| Nov 2, 1991 | Kentucky 20, Cincinnati 17 | Box score |
| Nov 2, 1991 | Louisiana 13, Northern Illinois 12 | Box score |
| Nov 2, 1991 | LSU 25, Ole Miss 22upset | Box score |
| Nov 2, 1991 | 4Michigan 42, Purdue 0 | Box score |
| Nov 2, 1991 | 15Colorado 19, 9Nebraska 19 | Box score |
| Nov 2, 1991 | New Mexico 34, Air Force 32upset | Box score |
| Nov 2, 1991 | New Mexico State 35, Cal State Fullerton 12 | Box score |
| Nov 2, 1991 | North Carolina 24, Maryland 0 | Box score |
| Nov 2, 1991 | 19NC State 38, South Carolina 21 | Box score |
| Nov 2, 1991 | Northwestern 16, Michigan State 13upset | Box score |
| Nov 2, 1991 | 5Notre Dame 38, Navy 0 | Box score |
| Nov 2, 1991 | 20Oklahoma 28, Kansas State 7 | Box score |
| Nov 2, 1991 | Pacific 51, Long Beach State 24 | Box score |
| Nov 2, 1991 | San Diego State 24, Wyoming 22 | Box score |
| Nov 2, 1991 | San José State 55, UNLV 12 | Box score |
| Nov 2, 1991 | Stanford 33, Oregon 13 | Box score |
| Nov 2, 1991 | 18Syracuse 27, Temple 6 | Box score |
| Nov 2, 1991 | 14Tennessee 52, Memphis 24 | Box score |
| Nov 2, 1991 | Texas 23, Texas Tech 15 | Box score |
| Nov 2, 1991 | 12Texas A&M 38, Rice 21 | Box score |
| Nov 2, 1991 | TCU 18, SMU 10 | Box score |
| Nov 2, 1991 | Tulsa 13, Southern Miss 10 | Box score |
| Nov 2, 1991 | 23UCLA 44, Washington State 3 | Box score |
| Nov 2, 1991 | Utah State 20, 25Fresno State 19upset | Box score |
| Nov 2, 1991 | Vanderbilt 41, Army 10upset | Box score |
| Nov 2, 1991 | 3Washington 44, Arizona State 16 | Box score |
| Nov 2, 1991 | West Virginia 28, Rutgers 3 | Box score |