| Oct 19, 1991 | Akron 28, Arkansas State 23 | Box score |
| Oct 19, 1991 | 14Alabama 24, 8Tennessee 19upset | Box score |
| Oct 19, 1991 | Arkansas 14, Texas 13 | Box score |
| Oct 19, 1991 | Army 37, Louisville 12 | Box score |
| Oct 19, 1991 | Bowling Green 24, Toledo 21 | Box score |
| Oct 19, 1991 | BYU 35, Hawai’i 18 | Box score |
| Oct 19, 1991 | Central Michigan 23, Kent State 7 | Box score |
| Oct 19, 1991 | 22Colorado 34, 12Oklahoma 17upset | Box score |
| Oct 19, 1991 | Eastern Michigan 42, Western Michigan 24upset | Box score |
| Oct 19, 1991 | 6Florida 41, Northern Illinois 10 | Box score |
| Oct 19, 1991 | Fresno State 42, New Mexico State 28 | Box score |
| Oct 19, 1991 | Houston 49, SMU 20 | Box score |
| Oct 19, 1991 | 15Iowa 24, 13Illinois 21upset | Box score |
| Oct 19, 1991 | Kansas 41, Iowa State 0 | Box score |
| Oct 19, 1991 | LSU 29, Kentucky 26 | Box score |
| Oct 19, 1991 | Maryland 23, Wake Forest 22 | Box score |
| Oct 19, 1991 | Memphis 28, Mississippi State 23upset | Box score |
| Oct 19, 1991 | 2Miami 55, Long Beach State 0 | Box score |
| Oct 19, 1991 | Miami (OH) 34, Ohio 0 | Box score |
| Oct 19, 1991 | 4Michigan 24, Indiana 16 | Box score |
| Oct 19, 1991 | Michigan State 20, Minnesota 12 | Box score |
| Oct 19, 1991 | Missouri 41, Oklahoma State 7 | Box score |
| Oct 19, 1991 | 9Nebraska 38, Kansas State 31 | Box score |
| Oct 19, 1991 | 5Notre Dame 28, Air Force 15 | Box score |
| Oct 19, 1991 | 18Ohio State 34, Northwestern 3 | Box score |
| Oct 19, 1991 | 10Penn State 37, Rutgers 17 | Box score |
| Oct 19, 1991 | Purdue 28, Wisconsin 7 | Box score |
| Oct 19, 1991 | San Diego State 28, UTEP 21 | Box score |
| Oct 19, 1991 | San José State 64, Pacific 47 | Box score |
| Oct 19, 1991 | South Carolina 23, Georgia Tech 14 | Box score |
| Oct 19, 1991 | Southern Miss 47, Tulane 14 | Box score |
| Oct 19, 1991 | Stanford 24, USC 21upset | Box score |
| Oct 19, 1991 | 24Syracuse 31, 20Pittsburgh 27upset | Box score |
| Oct 19, 1991 | Temple 21, Navy 14 | Box score |
| Oct 19, 1991 | 19Texas A&M 34, 16Baylor 12upset | Box score |
| Oct 19, 1991 | TCU 39, Rice 28 | Box score |
| Oct 19, 1991 | UCLA 44, Oregon State 7 | Box score |
| Oct 19, 1991 | Utah 21, Colorado State 16 | Box score |
| Oct 19, 1991 | Utah State 26, Cal State Fullerton 3 | Box score |
| Oct 19, 1991 | Vanderbilt 27, 17Georgia 25upset | Box score |
| Oct 19, 1991 | Virginia 14, North Carolina 9 | Box score |
| Oct 19, 1991 | Virginia Tech 56, Cincinnati 9 | Box score |
| Oct 19, 1991 | 3Washington 24, 7California 17 | Box score |
| Oct 19, 1991 | Washington State 17, 25Arizona State 3upset | Box score |
| Oct 19, 1991 | West Virginia 31, Boston College 24 | Box score |
| Oct 19, 1991 | Wyoming 39, New Mexico 19 | Box score |