| Oct 12, 1991 | Air Force 46, Navy 6 | Box score |
| Oct 12, 1991 | 19Alabama 62, Tulane 0 | Box score |
| Oct 12, 1991 | Arizona State 24, Oregon State 7 | Box score |
| Oct 12, 1991 | Arkansas 29, Houston 17 | Box score |
| Oct 12, 1991 | 24Auburn 24, Vanderbilt 22 | Box score |
| Oct 12, 1991 | Ball State 10, Eastern Michigan 8 | Box score |
| Oct 12, 1991 | Boston College 33, Louisville 3 | Box score |
| Oct 12, 1991 | Bowling Green 45, Ohio 14 | Box score |
| Oct 12, 1991 | BYU 31, UTEP 29 | Box score |
| Oct 12, 1991 | 13California 45, Oregon 7 | Box score |
| Oct 12, 1991 | Cincinnati 38, Kent State 19 | Box score |
| Oct 12, 1991 | 25Colorado 55, Missouri 7 | Box score |
| Oct 12, 1991 | East Carolina 23, 15Syracuse 20upset | Box score |
| Oct 12, 1991 | 10Florida 35, 4Tennessee 18upset | Box score |
| Oct 12, 1991 | 1Florida State 33, Virginia Tech 20 | Box score |
| Oct 12, 1991 | Fresno State 42, Long Beach State 14 | Box score |
| Oct 12, 1991 | 22Georgia 37, 23Ole Miss 17 | Box score |
| Oct 12, 1991 | Georgia Tech 34, Maryland 10 | Box score |
| Oct 12, 1991 | 20Illinois 10, 11Ohio State 7upset | Box score |
| Oct 12, 1991 | Indiana 44, Northwestern 6 | Box score |
| Oct 12, 1991 | 17Iowa 10, Wisconsin 6 | Box score |
| Oct 12, 1991 | Kansas State 16, Kansas 12 | Box score |
| Oct 12, 1991 | LSU 70, Arkansas State 14 | Box score |
| Oct 12, 1991 | South Carolina 12, Louisiana Tech 12 | Box score |
| Oct 12, 1991 | Memphis 17, Southern Miss 12 | Box score |
| Oct 12, 1991 | 2Miami 26, 9Penn State 20 | Box score |
| Oct 12, 1991 | Central Michigan 10, Miami (OH) 10 | Box score |
| Oct 12, 1991 | 5Michigan 45, Michigan State 28 | Box score |
| Oct 12, 1991 | Minnesota 6, Purdue 3 | Box score |
| Oct 12, 1991 | Mississippi State 31, Kentucky 6 | Box score |
| Oct 12, 1991 | 14Nebraska 49, Oklahoma State 15 | Box score |
| Oct 12, 1991 | UNLV 25, Cal State Fullerton 3 | Box score |
| Oct 12, 1991 | North Carolina 24, Wake Forest 10 | Box score |
| Oct 12, 1991 | 7Notre Dame 42, 12Pittsburgh 7 | Box score |
| Oct 12, 1991 | Rice 20, 8Baylor 17upset | Box score |
| Oct 12, 1991 | San Diego State 38, New Mexico 24 | Box score |
| Oct 12, 1991 | San José State 39, New Mexico State 13 | Box score |
| Oct 12, 1991 | USC 34, Washington State 27 | Box score |
| Oct 12, 1991 | Texas 10, 6Oklahoma 7upset | Box score |
| Oct 12, 1991 | Texas Tech 38, SMU 14 | Box score |
| Oct 12, 1991 | Tulsa 34, Louisiana 20 | Box score |
| Oct 12, 1991 | UCLA 54, Arizona 14 | Box score |
| Oct 12, 1991 | Utah 57, Wyoming 42 | Box score |
| Oct 12, 1991 | 18Clemson 20, Virginia 20 | Box score |
| Oct 12, 1991 | 3Washington 48, Toledo 0 | Box score |
| Oct 12, 1991 | West Virginia 10, Temple 9 | Box score |
| Oct 12, 1991 | Western Michigan 22, Northern Illinois 10 | Box score |