| Sep 19, 1991 | 17Georgia Tech 24, Virginia 21 | Box score |
| Sep 21, 1991 | Air Force 21, San Diego State 20 | Box score |
| Sep 21, 1991 | Alabama 10, 25Georgia 0upset | Box score |
| Sep 21, 1991 | Arizona State 32, 22USC 25upset | Box score |
| Sep 21, 1991 | Arkansas 9, Louisiana 7 | Box score |
| Sep 21, 1991 | 13Auburn 14, Texas 10 | Box score |
| Sep 21, 1991 | Ball State 28, Kent State 27 | Box score |
| Sep 21, 1991 | 14Baylor 47, Missouri 21 | Box score |
| Sep 21, 1991 | Bowling Green 20, Cincinnati 16 | Box score |
| Sep 21, 1991 | 24California 23, Arizona 21 | Box score |
| Sep 21, 1991 | Central Michigan 31, Akron 29 | Box score |
| Sep 21, 1991 | 8Clemson 37, Temple 7 | Box score |
| Sep 21, 1991 | 19Colorado 58, Minnesota 0 | Box score |
| Sep 21, 1991 | Fresno State 24, Oregon State 20 | Box score |
| Sep 21, 1991 | Hawai’i 30, Pacific 21 | Box score |
| Sep 21, 1991 | Illinois 51, 21Houston 10upset | Box score |
| Sep 21, 1991 | Indiana 13, Kentucky 10 | Box score |
| Sep 21, 1991 | Kansas 54, New Mexico State 14 | Box score |
| Sep 21, 1991 | Kansas State 34, Northern Illinois 17 | Box score |
| Sep 21, 1991 | LSU 16, Vanderbilt 14 | Box score |
| Sep 21, 1991 | Louisiana Tech 17, Eastern Michigan 14 | Box score |
| Sep 21, 1991 | Memphis 31, Arkansas State 21 | Box score |
| Sep 21, 1991 | Ole Miss 38, Ohio 14 | Box score |
| Sep 21, 1991 | UNLV 23, New Mexico 22 | Box score |
| Sep 21, 1991 | North Carolina 20, Army 12 | Box score |
| Sep 21, 1991 | NC State 30, Wake Forest 3 | Box score |
| Sep 21, 1991 | 11Notre Dame 49, Michigan State 10 | Box score |
| Sep 21, 1991 | 16Ohio State 33, Washington State 19 | Box score |
| Sep 21, 1991 | 7Oklahoma 55, Utah State 21 | Box score |
| Sep 21, 1991 | 12Penn State 33, BYU 7 | Box score |
| Sep 21, 1991 | Rice 28, Tulane 19 | Box score |
| Sep 21, 1991 | Rutgers 22, Northwestern 18 | Box score |
| Sep 21, 1991 | San José State 32, Long Beach State 20 | Box score |
| Sep 21, 1991 | South Carolina 28, Virginia Tech 21 | Box score |
| Sep 21, 1991 | Southern Miss 39, Colorado State 7 | Box score |
| Sep 21, 1991 | 18Syracuse 38, 5Florida 21upset | Box score |
| Sep 21, 1991 | 6Tennessee 26, 23Mississippi State 24 | Box score |
| Sep 21, 1991 | TCU 24, Oklahoma State 21 | Box score |
| Sep 21, 1991 | Toledo 23, Western Michigan 13 | Box score |
| Sep 21, 1991 | Tulsa 35, 15Texas A&M 34upset | Box score |
| Sep 21, 1991 | Utah 24, Oregon 17upset | Box score |
| Sep 21, 1991 | 4Washington 36, 9Nebraska 21 | Box score |
| Sep 21, 1991 | West Virginia 37, Maryland 7 | Box score |
| Sep 21, 1991 | Wisconsin 7, Iowa State 6 | Box score |
| Sep 21, 1991 | Wyoming 22, Texas Tech 17 | Box score |