| Sep 12, 1991 | 2Miami 40, 10Houston 10 | Box score |
| Sep 14, 1991 | Air Force 24, Utah 21 | Box score |
| Sep 14, 1991 | Arizona 28, Stanford 23 | Box score |
| Sep 14, 1991 | Arizona State 30, Oklahoma State 3 | Box score |
| Sep 14, 1991 | 15Auburn 23, Ole Miss 13 | Box score |
| Sep 14, 1991 | 23Baylor 16, 12Colorado 14upset | Box score |
| Sep 14, 1991 | California 42, Purdue 18 | Box score |
| Sep 14, 1991 | Central Michigan 20, 18Michigan State 3upset | Box score |
| Sep 14, 1991 | Duke 42, Rutgers 22 | Box score |
| Sep 14, 1991 | East Carolina 20, Memphis 13 | Box score |
| Sep 14, 1991 | 6Florida 35, 16Alabama 0 | Box score |
| Sep 14, 1991 | 1Florida State 58, Western Michigan 0 | Box score |
| Sep 14, 1991 | Fresno State 34, Washington State 30 | Box score |
| Sep 14, 1991 | 17Georgia Tech 30, Boston College 14 | Box score |
| Sep 14, 1991 | Hawai’i 35, New Mexico 13 | Box score |
| Sep 14, 1991 | 14Iowa 29, Iowa State 10 | Box score |
| Sep 14, 1991 | Kansas 23, Tulsa 17 | Box score |
| Sep 14, 1991 | Miami (OH) 29, Eastern Michigan 3 | Box score |
| Sep 14, 1991 | 3Michigan 24, 7Notre Dame 14 | Box score |
| Sep 14, 1991 | Minnesota 26, San José State 20 | Box score |
| Sep 14, 1991 | 25Mississippi State 48, Tulane 0 | Box score |
| Sep 14, 1991 | Missouri 23, Illinois 19 | Box score |
| Sep 14, 1991 | 13Nebraska 71, Colorado State 14 | Box score |
| Sep 14, 1991 | UNLV 23, Oregon State 9 | Box score |
| Sep 14, 1991 | North Carolina 51, Cincinnati 16 | Box score |
| Sep 14, 1991 | NC State 47, Kent State 0 | Box score |
| Sep 14, 1991 | Northern Illinois 22, Arkansas State 21 | Box score |
| Sep 14, 1991 | 19Ohio State 23, Louisville 15 | Box score |
| Sep 14, 1991 | Oregon 28, Texas Tech 13 | Box score |
| Sep 14, 1991 | 24Pittsburgh 26, Temple 7 | Box score |
| Sep 14, 1991 | Rice 36, Northwestern 7 | Box score |
| Sep 14, 1991 | San Diego State 55, Pacific 34 | Box score |
| Sep 14, 1991 | USC 21, 5Penn State 10upset | Box score |
| Sep 14, 1991 | 22Syracuse 31, Maryland 17 | Box score |
| Sep 14, 1991 | 11Tennessee 30, 21UCLA 16 | Box score |
| Sep 14, 1991 | 20Texas A&M 45, LSU 7 | Box score |
| Sep 14, 1991 | TCU 22, Ball State 16 | Box score |
| Sep 14, 1991 | UTEP 22, New Mexico State 21 | Box score |
| Sep 14, 1991 | Vanderbilt 14, SMU 11 | Box score |
| Sep 14, 1991 | Virginia 17, Navy 10 | Box score |
| Sep 14, 1991 | West Virginia 21, South Carolina 16 | Box score |
| Sep 14, 1991 | Wyoming 28, Louisiana 15 | Box score |