| Sep 5, 1991 | 11Tennessee 28, Louisville 11 | Box score |
| Sep 7, 1991 | Air Force 31, Colorado State 26 | Box score |
| Sep 7, 1991 | 20Alabama 41, Temple 3 | Box score |
| Sep 7, 1991 | Arkansas 17, SMU 6 | Box score |
| Sep 7, 1991 | Ball State 33, Navy 10 | Box score |
| Sep 7, 1991 | Baylor 27, UTEP 7 | Box score |
| Sep 7, 1991 | California 86, Pacific 24 | Box score |
| Sep 7, 1991 | Central Michigan 27, Louisiana 24 | Box score |
| Sep 7, 1991 | 12Colorado 30, Wyoming 13 | Box score |
| Sep 7, 1991 | South Carolina 24, Duke 24 | Box score |
| Sep 7, 1991 | 6Florida 59, San José State 21 | Box score |
| Sep 7, 1991 | 1Florida State 38, Tulane 11 | Box score |
| Sep 7, 1991 | Fresno State 55, Northern Illinois 7 | Box score |
| Sep 7, 1991 | Georgia 31, LSU 10 | Box score |
| Sep 7, 1991 | 15Iowa 53, Hawai’i 10 | Box score |
| Sep 7, 1991 | Kansas 30, Toledo 7upset | Box score |
| Sep 7, 1991 | Kentucky 23, Miami (OH) 20 | Box score |
| Sep 7, 1991 | Maryland 17, Virginia 6 | Box score |
| Sep 7, 1991 | 2Michigan 35, Boston College 13 | Box score |
| Sep 7, 1991 | Ole Miss 10, Memphis 0 | Box score |
| Sep 7, 1991 | Mississippi State 13, 13Texas 6upset | Box score |
| Sep 7, 1991 | 14Nebraska 59, Utah State 28 | Box score |
| Sep 7, 1991 | NC State 7, Virginia Tech 0 | Box score |
| Sep 7, 1991 | 7Notre Dame 49, Indiana 27 | Box score |
| Sep 7, 1991 | 22Ohio State 38, Arizona 14 | Box score |
| Sep 7, 1991 | Oregon 40, Washington State 14 | Box score |
| Sep 7, 1991 | 5Penn State 81, Cincinnati 0 | Box score |
| Sep 7, 1991 | Pittsburgh 35, Southern Miss 14 | Box score |
| Sep 7, 1991 | Purdue 49, Eastern Michigan 3 | Box score |
| Sep 7, 1991 | 24Syracuse 37, Vanderbilt 10 | Box score |
| Sep 7, 1991 | TCU 60, New Mexico 7 | Box score |
| Sep 7, 1991 | Texas Tech 41, Cal State Fullerton 7 | Box score |
| Sep 7, 1991 | Tulsa 13, Oklahoma State 7 | Box score |
| Sep 7, 1991 | 23UCLA 27, 25BYU 23 | Box score |
| Sep 7, 1991 | Utah 22, Oregon State 10 | Box score |
| Sep 7, 1991 | 4Washington 42, Stanford 7 | Box score |
| Sep 7, 1991 | West Virginia 24, Bowling Green 17 | Box score |
| Sep 7, 1991 | Western Michigan 35, Akron 12 | Box score |
| Sep 8, 1991 | San Diego State 49, Long Beach State 13 | Box score |