| Sep 26, 1991 | UCLA 37, San Diego State 12 | Box score |
| Sep 28, 1991 | 22Alabama 48, Vanderbilt 17 | Box score |
| Sep 28, 1991 | Arizona 45, Long Beach State 21 | Box score |
| Sep 28, 1991 | 12Baylor 45, SMU 7 | Box score |
| Sep 28, 1991 | Bowling Green 22, Navy 19 | Box score |
| Sep 28, 1991 | BYU 21, Air Force 7 | Box score |
| Sep 28, 1991 | Toledo 16, Central Michigan 16 | Box score |
| Sep 28, 1991 | 7Clemson 9, 19Georgia Tech 7 | Box score |
| Sep 28, 1991 | Colorado State 28, Hawai’i 16 | Box score |
| Sep 28, 1991 | East Carolina 31, South Carolina 20 | Box score |
| Sep 28, 1991 | 14Florida 29, 21Mississippi State 7 | Box score |
| Sep 28, 1991 | 1Florida State 51, 3Michigan 31 | Box score |
| Sep 28, 1991 | Georgia 27, Cal State Fullerton 14 | Box score |
| Sep 28, 1991 | Missouri 27, Indiana 27 | Box score |
| Sep 28, 1991 | 9Iowa 58, Northern Illinois 7 | Box score |
| Sep 28, 1991 | Iowa State 28, Rice 27upset | Box score |
| Sep 28, 1991 | Kentucky 24, Kent State 6 | Box score |
| Sep 28, 1991 | Louisiana Tech 42, Arkansas State 10 | Box score |
| Sep 28, 1991 | Louisville 28, Southern Miss 14 | Box score |
| Sep 28, 1991 | 2Miami 34, Tulsa 10 | Box score |
| Sep 28, 1991 | Miami (OH) 22, Cincinnati 9 | Box score |
| Sep 28, 1991 | Ole Miss 24, Arkansas 17 | Box score |
| Sep 28, 1991 | 16Nebraska 18, 24Arizona State 9 | Box score |
| Sep 28, 1991 | New Mexico 17, New Mexico State 10 | Box score |
| Sep 28, 1991 | NC State 24, 23North Carolina 7upset | Box score |
| Sep 28, 1991 | Northwestern 41, Wake Forest 14 | Box score |
| Sep 28, 1991 | 8Notre Dame 45, Purdue 20 | Box score |
| Sep 28, 1991 | 6Oklahoma 27, Virginia Tech 17 | Box score |
| Sep 28, 1991 | 10Penn State 28, Boston College 21 | Box score |
| Sep 28, 1991 | 18Pittsburgh 14, Minnesota 13 | Box score |
| Sep 28, 1991 | Rutgers 14, Michigan State 7upset | Box score |
| Sep 28, 1991 | San José State 23, Utah State 7 | Box score |
| Sep 28, 1991 | USC 30, Oregon 14 | Box score |
| Sep 28, 1991 | Stanford 28, 17Colorado 21upset | Box score |
| Sep 28, 1991 | 10Syracuse 24, Tulane 0 | Box score |
| Sep 28, 1991 | 5Tennessee 30, 13Auburn 21 | Box score |
| Sep 28, 1991 | Texas A&M 34, Louisiana 7 | Box score |
| Sep 28, 1991 | TCU 30, Texas Tech 16 | Box score |
| Sep 28, 1991 | Wyoming 28, UTEP 28 | Box score |
| Sep 28, 1991 | Virginia 34, Duke 3 | Box score |
| Sep 28, 1991 | 4Washington 56, Kansas State 3 | Box score |
| Sep 28, 1991 | Washington State 40, UNLV 13 | Box score |
| Sep 28, 1991 | Western Michigan 35, Ohio 9 | Box score |
| Sep 28, 1991 | Wisconsin 21, Eastern Michigan 6 | Box score |