| Oct 13, 1990 | 6Auburn 56, Vanderbilt 6 | Box score |
| Oct 13, 1990 | Ball State 31, Kent State 0 | Box score |
| Oct 13, 1990 | Baylor 52, SMU 17 | Box score |
| Oct 13, 1990 | Boston College 41, Army 20 | Box score |
| Oct 13, 1990 | 13BYU 52, Colorado State 9 | Box score |
| Oct 13, 1990 | California 31, Arizona State 24 | Box score |
| Oct 13, 1990 | Central Michigan 20, Western Michigan 13 | Box score |
| Oct 13, 1990 | 14Colorado 28, Iowa State 12 | Box score |
| Oct 13, 1990 | 18Georgia Tech 21, 15Clemson 19upset | Box score |
| Oct 13, 1990 | 12Houston 36, 20Texas A&M 31 | Box score |
| Oct 13, 1990 | 11Illinois 34, Purdue 0 | Box score |
| Oct 13, 1990 | 25Iowa 30, Wisconsin 10 | Box score |
| Oct 13, 1990 | Kansas State 23, Oklahoma State 17 | Box score |
| Oct 13, 1990 | Kentucky 17, Mississippi State 15 | Box score |
| Oct 13, 1990 | Louisiana Tech 35, Tulsa 21 | Box score |
| Oct 13, 1990 | Louisville 19, Memphis 17 | Box score |
| Oct 13, 1990 | Maryland 41, Wake Forest 13 | Box score |
| Oct 13, 1990 | 3Miami 34, Kansas 0 | Box score |
| Oct 13, 1990 | Miami (OH) 40, Ohio 18 | Box score |
| Oct 13, 1990 | Michigan State 28, 1Michigan 27upset | Box score |
| Oct 13, 1990 | Minnesota 35, Northwestern 25 | Box score |
| Oct 13, 1990 | 24Ole Miss 28, Georgia 12 | Box score |
| Oct 13, 1990 | Navy 17, Akron 13 | Box score |
| Oct 13, 1990 | 7Nebraska 69, Missouri 21 | Box score |
| Oct 13, 1990 | UNLV 24, New Mexico State 20 | Box score |
| Oct 13, 1990 | Northern Illinois 35, Arkansas State 0 | Box score |
| Oct 13, 1990 | 8Notre Dame 57, Air Force 27 | Box score |
| Oct 13, 1990 | 22Indiana 27, Ohio State 27 | Box score |
| Oct 13, 1990 | Oregon State 35, 21Arizona 21upset | Box score |
| Oct 13, 1990 | Pacific 67, Cal State Fullerton 37upset | Box score |
| Oct 13, 1990 | Penn State 27, Syracuse 21 | Box score |
| Oct 13, 1990 | Pittsburgh 45, Rutgers 21 | Box score |
| Oct 13, 1990 | San José State 46, Long Beach State 29 | Box score |
| Oct 13, 1990 | South Carolina 37, East Carolina 7 | Box score |
| Oct 13, 1990 | 16USC 37, Stanford 22 | Box score |
| Oct 13, 1990 | Southern Miss 20, Tulane 14 | Box score |
| Oct 13, 1990 | 5Tennessee 45, 9Florida 3 | Box score |
| Oct 13, 1990 | Texas 14, 4Oklahoma 13upset | Box score |
| Oct 13, 1990 | TCU 38, Rice 28 | Box score |
| Oct 13, 1990 | Texas Tech 49, Arkansas 44upset | Box score |
| Oct 13, 1990 | UTEP 12, Hawai’i 10upset | Box score |
| Oct 13, 1990 | Toledo 19, Bowling Green 13 | Box score |
| Oct 13, 1990 | UCLA 45, San Diego State 31 | Box score |
| Oct 13, 1990 | Fresno State 24, Utah State 24 | Box score |
| Oct 13, 1990 | 2Virginia 31, NC State 0 | Box score |
| Oct 13, 1990 | 17Washington 38, 19Oregon 17 | Box score |
| Oct 13, 1990 | West Virginia 28, Cincinnati 20 | Box score |
| Oct 13, 1990 | 23Wyoming 25, New Mexico 22 | Box score |