| Oct 6, 1990 | Air Force 24, Navy 7 | Box score |
| Oct 6, 1990 | Alabama 25, Louisiana 6 | Box score |
| Oct 6, 1990 | 25Arizona 28, UCLA 21 | Box score |
| Oct 6, 1990 | 5Auburn 16, Louisiana Tech 14 | Box score |
| Oct 6, 1990 | Boston College 19, Rutgers 14 | Box score |
| Oct 6, 1990 | California 35, San José State 34 | Box score |
| Oct 6, 1990 | Central Michigan 42, Kent State 0 | Box score |
| Oct 6, 1990 | 16Clemson 34, Georgia 3 | Box score |
| Oct 6, 1990 | 12Colorado 33, Missouri 31 | Box score |
| Oct 6, 1990 | Colorado State 28, Utah 13 | Box score |
| Oct 6, 1990 | Duke 17, Army 16 | Box score |
| Oct 6, 1990 | 10Florida 34, LSU 8 | Box score |
| Oct 6, 1990 | 23Georgia Tech 31, Maryland 3 | Box score |
| Oct 6, 1990 | 13Houston 31, Baylor 15 | Box score |
| Oct 6, 1990 | 13Illinois 31, 20Ohio State 20 | Box score |
| Oct 6, 1990 | Indiana 42, Northwestern 0 | Box score |
| Oct 6, 1990 | Iowa 12, 18Michigan State 7upset | Box score |
| Oct 6, 1990 | Iowa State 34, Kansas 34 | Box score |
| Oct 6, 1990 | Long Beach State 31, New Mexico State 27 | Box score |
| Oct 6, 1990 | Louisville 38, Tulsa 14 | Box score |
| Oct 6, 1990 | Memphis 21, Tulane 14 | Box score |
| Oct 6, 1990 | 9Miami 31, 2Florida State 22upset | Box score |
| Oct 6, 1990 | Miami (OH) 24, Ball State 10upset | Box score |
| Oct 6, 1990 | 3Michigan 41, Wisconsin 3 | Box score |
| Oct 6, 1990 | Minnesota 19, Purdue 7 | Box score |
| Oct 6, 1990 | Ole Miss 35, Kentucky 29 | Box score |
| Oct 6, 1990 | 8Nebraska 45, Kansas State 8 | Box score |
| Oct 6, 1990 | UNLV 29, Cal State Fullerton 10 | Box score |
| Oct 6, 1990 | New Mexico 48, UTEP 28 | Box score |
| Oct 6, 1990 | North Carolina 31, Wake Forest 24 | Box score |
| Oct 6, 1990 | Northern Illinois 73, 24Fresno State 18upset | Box score |
| Oct 6, 1990 | Bowling Green 10, Ohio 10 | Box score |
| Oct 6, 1990 | 7Oklahoma 31, Oklahoma State 17 | Box score |
| Oct 6, 1990 | 22Oregon 52, Utah State 7 | Box score |
| Oct 6, 1990 | Penn State 48, Temple 10 | Box score |
| Oct 6, 1990 | 15USC 30, Washington State 17 | Box score |
| Oct 6, 1990 | Southern Miss 16, East Carolina 7 | Box score |
| Oct 6, 1990 | Stanford 36, 1Notre Dame 31upset | Box score |
| Oct 6, 1990 | Syracuse 49, Vanderbilt 14 | Box score |
| Oct 6, 1990 | Texas 26, Rice 10 | Box score |
| Oct 6, 1990 | 19Texas A&M 28, Texas Tech 24 | Box score |
| Oct 6, 1990 | TCU 54, 21Arkansas 26upset | Box score |
| Oct 6, 1990 | Toledo 37, Eastern Michigan 23 | Box score |
| Oct 6, 1990 | Virginia Tech 26, West Virginia 21 | Box score |
| Oct 6, 1990 | 17Washington 42, Arizona State 14 | Box score |
| Oct 6, 1990 | Western Michigan 24, Akron 20 | Box score |
| Oct 6, 1990 | Wyoming 52, San Diego State 51 | Box score |