| Sep 29, 1990 | Alabama 59, Vanderbilt 28 | Box score |
| Sep 29, 1990 | 23Arkansas 31, Colorado State 20 | Box score |
| Sep 29, 1990 | Ball State 16, Bowling Green 6 | Box score |
| Sep 29, 1990 | Baylor 21, Texas Tech 15 | Box score |
| Sep 29, 1990 | Boston College 28, Navy 17 | Box score |
| Sep 29, 1990 | California 30, 16Arizona 25upset | Box score |
| Sep 29, 1990 | Central Michigan 31, Miami (OH) 7 | Box score |
| Sep 29, 1990 | Cincinnati 27, Kent State 24 | Box score |
| Sep 29, 1990 | 19Clemson 26, Duke 7 | Box score |
| Sep 29, 1990 | 20Colorado 20, 12Washington 14upset | Box score |
| Sep 29, 1990 | 17Florida 34, Mississippi State 21 | Box score |
| Sep 29, 1990 | 2Florida State 39, Virginia Tech 28 | Box score |
| Sep 29, 1990 | 24Fresno State 38, Cal State Fullerton 3 | Box score |
| Sep 29, 1990 | Georgia 19, East Carolina 15 | Box score |
| Sep 29, 1990 | Georgia Tech 27, 25South Carolina 6upset | Box score |
| Sep 29, 1990 | 13Houston 24, Rice 22 | Box score |
| Sep 29, 1990 | Indiana 37, Eastern Michigan 6 | Box score |
| Sep 29, 1990 | Iowa State 34, Western Michigan 20 | Box score |
| Sep 29, 1990 | Kansas State 38, New Mexico 6 | Box score |
| Sep 29, 1990 | LSU 17, 11Texas A&M 8upset | Box score |
| Sep 29, 1990 | Louisiana Tech 24, Louisiana 10 | Box score |
| Sep 29, 1990 | Memphis 22, Tulsa 10 | Box score |
| Sep 29, 1990 | 10Miami 48, Iowa 21 | Box score |
| Sep 29, 1990 | 6Michigan 45, Maryland 17 | Box score |
| Sep 29, 1990 | 22Michigan State 34, Rutgers 10 | Box score |
| Sep 29, 1990 | Ole Miss 31, Tulane 21 | Box score |
| Sep 29, 1990 | Missouri 30, 21Arizona State 9upset | Box score |
| Sep 29, 1990 | 8Nebraska 31, Oregon State 7 | Box score |
| Sep 29, 1990 | UNLV 37, Pacific 28 | Box score |
| Sep 29, 1990 | NC State 12, North Carolina 9 | Box score |
| Sep 29, 1990 | Northwestern 24, Northern Illinois 7upset | Box score |
| Sep 29, 1990 | 1Notre Dame 37, Purdue 11 | Box score |
| Sep 29, 1990 | 9Oklahoma 31, Kansas 17 | Box score |
| Sep 29, 1990 | Oregon 32, 4BYU 16upset | Box score |
| Sep 29, 1990 | San Diego State 48, Air Force 18 | Box score |
| Sep 29, 1990 | San José State 29, Stanford 23 | Box score |
| Sep 29, 1990 | 18USC 35, 15Ohio State 26upset | Box score |
| Sep 29, 1990 | Southern Miss 25, Louisville 13 | Box score |
| Sep 29, 1990 | 3Auburn 26, 5Tennessee 26 | Box score |
| Sep 29, 1990 | TCU 42, SMU 21 | Box score |
| Sep 29, 1990 | Toledo 27, Ohio 20 | Box score |
| Sep 29, 1990 | UCLA 30, Washington State 20 | Box score |
| Sep 29, 1990 | Wake Forest 52, Army 14 | Box score |
| Sep 29, 1990 | West Virginia 38, Pittsburgh 24 | Box score |
| Sep 29, 1990 | Wyoming 28, Utah 10 | Box score |