| Sep 22, 1990 | Akron 48, Cal State Fullerton 17 | Box score |
| Sep 22, 1990 | 18Arizona 22, Oregon 17 | Box score |
| Sep 22, 1990 | 4BYU 62, San Diego State 34 | Box score |
| Sep 22, 1990 | Central Michigan 17, Bowling Green 0 | Box score |
| Sep 22, 1990 | 20Colorado 29, 22Texas 22 | Box score |
| Sep 22, 1990 | Colorado State 38, UTEP 20 | Box score |
| Sep 22, 1990 | East Carolina 20, Louisiana 10 | Box score |
| Sep 22, 1990 | 2Florida State 31, Tulane 13 | Box score |
| Sep 22, 1990 | Fresno State 42, New Mexico State 3 | Box score |
| Sep 22, 1990 | Georgia 17, Alabama 16 | Box score |
| Sep 22, 1990 | Hawai’i 19, Utah 7 | Box score |
| Sep 22, 1990 | Indiana 58, Missouri 7 | Box score |
| Sep 22, 1990 | Iowa 45, Iowa State 35 | Box score |
| Sep 22, 1990 | Long Beach State 28, Pacific 7 | Box score |
| Sep 22, 1990 | Louisiana Tech 40, Arkansas State 7 | Box score |
| Sep 22, 1990 | Louisville 9, West Virginia 7 | Box score |
| Sep 22, 1990 | Maryland 13, NC State 12 | Box score |
| Sep 22, 1990 | Miami (OH) 16, Cincinnati 12 | Box score |
| Sep 22, 1990 | 7Michigan 38, UCLA 15 | Box score |
| Sep 22, 1990 | Ole Miss 21, 13Arkansas 17upset | Box score |
| Sep 22, 1990 | Mississippi State 13, Southern Miss 10 | Box score |
| Sep 22, 1990 | 8Nebraska 56, Minnesota 0 | Box score |
| Sep 22, 1990 | North Carolina 16, Kentucky 13 | Box score |
| Sep 22, 1990 | Northern Illinois 42, Kansas State 35 | Box score |
| Sep 22, 1990 | 1Notre Dame 20, 24Michigan State 19 | Box score |
| Sep 22, 1990 | 11Oklahoma 52, Tulsa 10 | Box score |
| Sep 22, 1990 | Penn State 28, Rutgers 0 | Box score |
| Sep 22, 1990 | Syracuse 20, 25Pittsburgh 20 | Box score |
| Sep 22, 1990 | Rice 31, Northwestern 14 | Box score |
| Sep 22, 1990 | San José State 47, UNLV 13 | Box score |
| Sep 22, 1990 | South Carolina 35, Virginia Tech 24 | Box score |
| Sep 22, 1990 | Stanford 37, Oregon State 3 | Box score |
| Sep 22, 1990 | Temple 24, Wisconsin 18 | Box score |
| Sep 22, 1990 | TCU 31, Oklahoma State 21 | Box score |
| Sep 22, 1990 | Texas Tech 34, New Mexico 32 | Box score |
| Sep 22, 1990 | Toledo 28, Ball State 16 | Box score |
| Sep 22, 1990 | Vanderbilt 24, LSU 21upset | Box score |
| Sep 22, 1990 | 10Virginia 59, Duke 0 | Box score |
| Sep 22, 1990 | 21Washington 31, 5USC 0upset | Box score |
| Sep 22, 1990 | Washington State 41, California 31 | Box score |
| Sep 22, 1990 | Western Michigan 37, Kent State 10 | Box score |
| Sep 22, 1990 | Wyoming 24, Air Force 12 | Box score |