| Sep 13, 1990 | 18Houston 51, Texas Tech 35 | Box score |
| Sep 15, 1990 | 20Arizona 25, New Mexico 10 | Box score |
| Sep 15, 1990 | 25Arizona State 31, Colorado State 20 | Box score |
| Sep 15, 1990 | 15Arkansas 28, Tulsa 3 | Box score |
| Sep 15, 1990 | 2Auburn 24, Ole Miss 10 | Box score |
| Sep 15, 1990 | 5BYU 50, Washington State 36 | Box score |
| Sep 15, 1990 | Akron 14, Central Michigan 14 | Box score |
| Sep 15, 1990 | 16Clemson 18, Maryland 17 | Box score |
| Sep 15, 1990 | Eastern Michigan 21, Ohio 18 | Box score |
| Sep 15, 1990 | 24Florida 17, Alabama 13 | Box score |
| Sep 15, 1990 | Fresno State 31, Utah 7 | Box score |
| Sep 15, 1990 | Georgia 18, Southern Miss 17 | Box score |
| Sep 15, 1990 | 21Illinois 23, 9Colorado 22upset | Box score |
| Sep 15, 1990 | Indiana 45, Kentucky 24 | Box score |
| Sep 15, 1990 | Iowa 63, Cincinnati 10 | Box score |
| Sep 15, 1990 | Kansas State 52, New Mexico State 7 | Box score |
| Sep 15, 1990 | LSU 35, Miami (OH) 7 | Box score |
| Sep 15, 1990 | Louisville 28, Kansas 16 | Box score |
| Sep 15, 1990 | 10Miami 52, California 24 | Box score |
| Sep 15, 1990 | Syracuse 23, 19Michigan State 23 | Box score |
| Sep 15, 1990 | Minnesota 20, Iowa State 16 | Box score |
| Sep 15, 1990 | Mississippi State 27, Cal State Fullerton 13 | Box score |
| Sep 15, 1990 | Missouri 45, Utah State 10 | Box score |
| Sep 15, 1990 | UNLV 45, Oregon State 20 | Box score |
| Sep 15, 1990 | NC State 20, Wake Forest 15 | Box score |
| Sep 15, 1990 | 1Notre Dame 28, 4Michigan 24 | Box score |
| Sep 15, 1990 | 17Ohio State 31, Boston College 10 | Box score |
| Sep 15, 1990 | 14Oklahoma 52, 13Pittsburgh 10upset | Box score |
| Sep 15, 1990 | San Diego State 38, Long Beach State 20 | Box score |
| Sep 15, 1990 | San José State 28, Pacific 14 | Box score |
| Sep 15, 1990 | 6USC 19, Penn State 14 | Box score |
| Sep 15, 1990 | 7Tennessee 56, UTEP 0 | Box score |
| Sep 15, 1990 | 12Texas A&M 63, Louisiana 14 | Box score |
| Sep 15, 1990 | Toledo 23, Northern Illinois 14 | Box score |
| Sep 15, 1990 | Tulane 43, SMU 7 | Box score |
| Sep 15, 1990 | UCLA 32, Stanford 31 | Box score |
| Sep 15, 1990 | 11Virginia 56, Navy 14 | Box score |
| Sep 15, 1990 | Virginia Tech 24, East Carolina 23 | Box score |
| Sep 15, 1990 | 22Washington 20, Purdue 14 | Box score |
| Sep 15, 1990 | Western Michigan 27, Louisiana Tech 21 | Box score |
| Sep 15, 1990 | Wisconsin 24, Ball State 7upset | Box score |
| Sep 15, 1990 | Wyoming 34, Arkansas State 27 | Box score |