| Sep 6, 1990 | 6Colorado 21, Stanford 17 | Box score |
| Sep 8, 1990 | Air Force 27, Hawai’i 3 | Box score |
| Sep 8, 1990 | Akron 38, Kent State 10 | Box score |
| Sep 8, 1990 | Arizona 28, 11Illinois 16upset | Box score |
| Sep 8, 1990 | Arizona State 34, Baylor 13 | Box score |
| Sep 8, 1990 | 3Auburn 38, Cal State Fullerton 17 | Box score |
| Sep 8, 1990 | 16BYU 28, 1Miami 21upset | Box score |
| Sep 8, 1990 | California 28, Wisconsin 12 | Box score |
| Sep 8, 1990 | Central Michigan 34, Cincinnati 0 | Box score |
| Sep 8, 1990 | Duke 27, Northwestern 24 | Box score |
| Sep 8, 1990 | Eastern Michigan 27, Western Michigan 24 | Box score |
| Sep 8, 1990 | Florida 50, Oklahoma State 7 | Box score |
| Sep 8, 1990 | 3Florida State 45, East Carolina 24 | Box score |
| Sep 8, 1990 | Fresno State 24, New Mexico 17 | Box score |
| Sep 8, 1990 | Georgia Tech 21, NC State 13 | Box score |
| Sep 8, 1990 | 24Houston 37, UNLV 9 | Box score |
| Sep 8, 1990 | Kansas 38, Oregon State 12 | Box score |
| Sep 8, 1990 | LSU 18, Georgia 13 | Box score |
| Sep 8, 1990 | Maryland 14, 25West Virginia 10upset | Box score |
| Sep 8, 1990 | Ole Miss 23, Memphis 21 | Box score |
| Sep 8, 1990 | 10Nebraska 60, Northern Illinois 14 | Box score |
| Sep 8, 1990 | 18Ohio State 17, Texas Tech 10 | Box score |
| Sep 8, 1990 | 23Oklahoma 34, 19UCLA 14upset | Box score |
| Sep 8, 1990 | Oregon 42, San Diego State 21 | Box score |
| Sep 8, 1990 | 17Pittsburgh 29, Boston College 6 | Box score |
| Sep 8, 1990 | Rutgers 24, Kentucky 8 | Box score |
| Sep 8, 1990 | South Carolina 27, North Carolina 5 | Box score |
| Sep 8, 1990 | SMU 44, Vanderbilt 7 | Box score |
| Sep 8, 1990 | Southern Miss 27, 13Alabama 24upset | Box score |
| Sep 8, 1990 | Syracuse 19, Temple 9 | Box score |
| Sep 8, 1990 | 8Tennessee 40, Mississippi State 7 | Box score |
| Sep 8, 1990 | Texas 17, 21Penn State 13upset | Box score |
| Sep 8, 1990 | TCU 20, Missouri 19 | Box score |
| Sep 8, 1990 | UTEP 27, New Mexico State 24 | Box score |
| Sep 8, 1990 | Toledo 20, Miami (OH) 14 | Box score |
| Sep 8, 1990 | Tulane 21, Rice 10 | Box score |
| Sep 8, 1990 | Utah 35, Minnesota 29 | Box score |
| Sep 8, 1990 | Utah State 27, Long Beach State 13 | Box score |
| Sep 8, 1990 | 14Virginia 20, 9Clemson 7upset | Box score |
| Sep 8, 1990 | Virginia Tech 21, Bowling Green 7 | Box score |
| Sep 8, 1990 | 20Washington 20, San José State 17 | Box score |
| Sep 8, 1990 | Wyoming 34, Washington State 13 | Box score |