| Oct 20, 1990 | Alabama 9, 3Tennessee 6upset | Box score |
| Oct 20, 1990 | Arizona 35, 15USC 26upset | Box score |
| Oct 20, 1990 | 5Auburn 20, 7Florida State 17 | Box score |
| Oct 20, 1990 | 25Texas A&M 20, Baylor 20 | Box score |
| Oct 20, 1990 | Bowling Green 25, Eastern Michigan 15 | Box score |
| Oct 20, 1990 | California 38, UCLA 31 | Box score |
| Oct 20, 1990 | Central Michigan 13, Toledo 12 | Box score |
| Oct 20, 1990 | 22Clemson 24, NC State 17 | Box score |
| Oct 20, 1990 | 14Colorado 41, Kansas 10 | Box score |
| Oct 20, 1990 | Colorado State 47, New Mexico 7 | Box score |
| Oct 20, 1990 | East Carolina 56, Cincinnati 32 | Box score |
| Oct 20, 1990 | 17Florida 59, Akron 0 | Box score |
| Oct 20, 1990 | Fresno State 28, Long Beach State 16 | Box score |
| Oct 20, 1990 | Georgia 39, Vanderbilt 28 | Box score |
| Oct 20, 1990 | North Carolina 13, 11Georgia Tech 13 | Box score |
| Oct 20, 1990 | Hawai’i 45, Cal State Fullerton 21 | Box score |
| Oct 20, 1990 | 9Houston 44, SMU 17 | Box score |
| Oct 20, 1990 | 8Illinois 15, 24Michigan State 13 | Box score |
| Oct 20, 1990 | 22Iowa 24, 10Michigan 23upset | Box score |
| Oct 20, 1990 | Iowa State 33, 16Oklahoma 31upset | Box score |
| Oct 20, 1990 | Kent State 44, Ohio 15 | Box score |
| Oct 20, 1990 | Louisiana 25, Tulsa 13 | Box score |
| Oct 20, 1990 | LSU 30, Kentucky 20 | Box score |
| Oct 20, 1990 | Louisville 27, Pittsburgh 20 | Box score |
| Oct 20, 1990 | Maryland 23, Duke 20 | Box score |
| Oct 20, 1990 | Minnesota 12, 20Indiana 0upset | Box score |
| Oct 20, 1990 | 18Ole Miss 42, Arkansas State 13 | Box score |
| Oct 20, 1990 | Mississippi State 38, Tulane 17 | Box score |
| Oct 20, 1990 | Missouri 31, Kansas State 10 | Box score |
| Oct 20, 1990 | 4Nebraska 31, Oklahoma State 3 | Box score |
| Oct 20, 1990 | Northwestern 44, Wisconsin 34 | Box score |
| Oct 20, 1990 | 6Notre Dame 29, 2Miami 20upset | Box score |
| Oct 20, 1990 | Ohio State 42, Purdue 2 | Box score |
| Oct 20, 1990 | Oregon 27, Arizona State 7 | Box score |
| Oct 20, 1990 | Pacific 62, New Mexico State 24 | Box score |
| Oct 20, 1990 | Penn State 40, Boston College 21 | Box score |
| Oct 20, 1990 | Rice 42, Texas Tech 21upset | Box score |
| Oct 20, 1990 | San José State 34, Utah State 27 | Box score |
| Oct 20, 1990 | Southern Miss 23, Memphis 7 | Box score |
| Oct 20, 1990 | Syracuse 42, Rutgers 0 | Box score |
| Oct 20, 1990 | Temple 31, Virginia Tech 28 | Box score |
| Oct 20, 1990 | 19Texas 49, Arkansas 17 | Box score |
| Oct 20, 1990 | Utah 37, UTEP 23 | Box score |
| Oct 20, 1990 | 1Virginia 49, Wake Forest 14 | Box score |
| Oct 20, 1990 | 13Washington 52, Stanford 16 | Box score |
| Oct 20, 1990 | Washington State 55, Oregon State 24 | Box score |
| Oct 20, 1990 | Western Michigan 14, Ball State 13 | Box score |