| Sep 30, 1988 | BYU 38, Utah State 3 | Box score |
| Oct 1, 1988 | Air Force 63, New Mexico 14 | Box score |
| Oct 1, 1988 | 12Alabama 31, Kentucky 27 | Box score |
| Oct 1, 1988 | Arkansas 53, TCU 10 | Box score |
| Oct 1, 1988 | 4Auburn 47, North Carolina 21 | Box score |
| Oct 1, 1988 | Ball State 45, Miami (OH) 14 | Box score |
| Oct 1, 1988 | Boston College 34, Pittsburgh 31 | Box score |
| Oct 1, 1988 | California 21, San José State 14 | Box score |
| Oct 1, 1988 | Central Michigan 31, Kent State 7 | Box score |
| Oct 1, 1988 | Colorado 27, Colorado State 23 | Box score |
| Oct 1, 1988 | Duke 17, Vanderbilt 15 | Box score |
| Oct 1, 1988 | 17Florida 19, 14LSU 6upset | Box score |
| Oct 1, 1988 | 6Florida State 48, Tulane 28 | Box score |
| Oct 1, 1988 | 15Georgia 36, Ole Miss 12 | Box score |
| Oct 1, 1988 | Houston 27, Baylor 24 | Box score |
| Oct 1, 1988 | Illinois 31, Ohio State 12upset | Box score |
| Oct 1, 1988 | Indiana 48, Northwestern 17 | Box score |
| Oct 1, 1988 | Michigan State 10, Iowa 10 | Box score |
| Oct 1, 1988 | Louisiana 48, East Carolina 36 | Box score |
| Oct 1, 1988 | Memphis 31, Mississippi State 10 | Box score |
| Oct 1, 1988 | 1Miami 55, Missouri 0 | Box score |
| Oct 1, 1988 | 19Michigan 62, Wisconsin 14 | Box score |
| Oct 1, 1988 | 9Nebraska 48, UNLV 6 | Box score |
| Oct 1, 1988 | New Mexico State 42, Kansas 29upset | Box score |
| Oct 1, 1988 | NC State 14, Georgia Tech 6 | Box score |
| Oct 1, 1988 | 5Notre Dame 42, Stanford 14 | Box score |
| Oct 1, 1988 | Ohio 24, Toledo 14 | Box score |
| Oct 1, 1988 | 10Oklahoma 35, Iowa State 7 | Box score |
| Oct 1, 1988 | 13Oklahoma State 56, Tulsa 35 | Box score |
| Oct 1, 1988 | 20Oregon 34, San Diego State 13 | Box score |
| Oct 1, 1988 | Oregon State 21, Fresno State 10 | Box score |
| Oct 1, 1988 | Pacific 22, Long Beach State 10 | Box score |
| Oct 1, 1988 | Penn State 45, Temple 9 | Box score |
| Oct 1, 1988 | Purdue 14, Minnesota 10 | Box score |
| Oct 1, 1988 | Rutgers 38, Cincinnati 9 | Box score |
| Oct 1, 1988 | 3USC 38, Arizona 15 | Box score |
| Oct 1, 1988 | Southern Miss 30, Louisville 23 | Box score |
| Oct 1, 1988 | Syracuse 20, Maryland 9 | Box score |
| Oct 1, 1988 | Texas 20, Rice 13 | Box score |
| Oct 1, 1988 | Texas A&M 50, Texas Tech 15 | Box score |
| Oct 1, 1988 | UTEP 38, Utah 28 | Box score |
| Oct 1, 1988 | 2UCLA 24, 16Washington 17 | Box score |
| Oct 1, 1988 | Washington State 52, Tennessee 24 | Box score |
| Oct 1, 1988 | 7West Virginia 22, Virginia Tech 10 | Box score |
| Oct 1, 1988 | Western Michigan 37, Bowling Green 10 | Box score |
| Oct 1, 1988 | 18Wyoming 35, Cal State Fullerton 16 | Box score |