| Sep 24, 1988 | Akron 30, New Mexico 28 | Box score |
| Sep 24, 1988 | 13Alabama 44, Vanderbilt 10 | Box score |
| Sep 24, 1988 | Arizona 55, Eastern Michigan 0 | Box score |
| Sep 24, 1988 | Army 23, Northwestern 7 | Box score |
| Sep 24, 1988 | 4Auburn 38, Tennessee 6 | Box score |
| Sep 24, 1988 | Cal State Fullerton 13, Pacific 10 | Box score |
| Sep 24, 1988 | California 52, Kansas 21 | Box score |
| Sep 24, 1988 | Cincinnati 34, Miami (OH) 18 | Box score |
| Sep 24, 1988 | 12Clemson 30, Georgia Tech 13 | Box score |
| Sep 24, 1988 | Colorado 28, Oregon State 21 | Box score |
| Sep 24, 1988 | Duke 38, Virginia 34 | Box score |
| Sep 24, 1988 | 20Florida 17, Mississippi State 0 | Box score |
| Sep 24, 1988 | 9Florida State 30, Michigan State 7 | Box score |
| Sep 24, 1988 | Hawai’i 48, Utah 20 | Box score |
| Sep 24, 1988 | Missouri 28, Indiana 28 | Box score |
| Sep 24, 1988 | Iowa 10, Iowa State 3 | Box score |
| Sep 24, 1988 | Kentucky 38, Kent State 14 | Box score |
| Sep 24, 1988 | Louisiana 41, Rice 16 | Box score |
| Sep 24, 1988 | Louisville 38, North Carolina 34upset | Box score |
| Sep 24, 1988 | Maryland 30, NC State 26 | Box score |
| Sep 24, 1988 | 1Miami 23, Wisconsin 3 | Box score |
| Sep 24, 1988 | 19Michigan 19, Wake Forest 9 | Box score |
| Sep 24, 1988 | Minnesota 31, Northern Illinois 20 | Box score |
| Sep 24, 1988 | 10Nebraska 47, Arizona State 16 | Box score |
| Sep 24, 1988 | UNLV 26, Ohio 18 | Box score |
| Sep 24, 1988 | 8Notre Dame 52, Purdue 7 | Box score |
| Sep 24, 1988 | Ohio State 36, 7LSU 33upset | Box score |
| Sep 24, 1988 | 18Oklahoma State 52, Texas A&M 15 | Box score |
| Sep 24, 1988 | Oregon 7, Stanford 3 | Box score |
| Sep 24, 1988 | Rutgers 21, 15Penn State 16upset | Box score |
| Sep 24, 1988 | 14South Carolina 23, 6Georgia 10upset | Box score |
| Sep 24, 1988 | 5USC 23, 3Oklahoma 7upset | Box score |
| Sep 24, 1988 | Southern Miss 45, East Carolina 42 | Box score |
| Sep 24, 1988 | Syracuse 35, Virginia Tech 0 | Box score |
| Sep 24, 1988 | TCU 31, Boston College 17 | Box score |
| Sep 24, 1988 | Texas Tech 36, Baylor 6 | Box score |
| Sep 24, 1988 | UTEP 27, Tulsa 24 | Box score |
| Sep 24, 1988 | Toledo 34, Bowling Green 5 | Box score |
| Sep 24, 1988 | Tulane 20, Memphis 19 | Box score |
| Sep 24, 1988 | Utah State 32, New Mexico State 20 | Box score |
| Sep 24, 1988 | 17Washington 35, San José State 31 | Box score |
| Sep 24, 1988 | 11West Virginia 31, 16Pittsburgh 10 | Box score |
| Sep 24, 1988 | Wyoming 48, Air Force 45 | Box score |