| Sep 17, 1988 | Air Force 62, Northwestern 27 | Box score |
| Sep 17, 1988 | Arizona State 28, Colorado State 17 | Box score |
| Sep 17, 1988 | Arkansas 21, Ole Miss 13 | Box score |
| Sep 17, 1988 | 6Auburn 56, Kansas 7 | Box score |
| Sep 17, 1988 | Baylor 35, Iowa State 0 | Box score |
| Sep 17, 1988 | BYU 31, UTEP 27 | Box score |
| Sep 17, 1988 | Cal State Fullerton 20, UNLV 10 | Box score |
| Sep 17, 1988 | Central Michigan 27, Akron 16 | Box score |
| Sep 17, 1988 | Colorado 24, 19Iowa 21upset | Box score |
| Sep 17, 1988 | Eastern Michigan 21, Kent State 14 | Box score |
| Sep 17, 1988 | 10Florida State 24, 3Clemson 21upset | Box score |
| Sep 17, 1988 | Fresno State 41, New Mexico State 0 | Box score |
| Sep 17, 1988 | 7Georgia 42, Mississippi State 35 | Box score |
| Sep 17, 1988 | Hawai’i 36, San José State 27 | Box score |
| Sep 17, 1988 | Houston 31, Missouri 7 | Box score |
| Sep 17, 1988 | Illinois 35, Utah 24 | Box score |
| Sep 17, 1988 | Indiana 36, Kentucky 15 | Box score |
| Sep 17, 1988 | 9LSU 34, Tennessee 9 | Box score |
| Sep 17, 1988 | Louisville 29, Memphis 18 | Box score |
| Sep 17, 1988 | 1Miami 31, 15Michigan 30 | Box score |
| Sep 17, 1988 | Minnesota 35, Miami (OH) 3 | Box score |
| Sep 17, 1988 | NC State 14, Wake Forest 6 | Box score |
| Sep 17, 1988 | Northern Illinois 19, Wisconsin 17 | Box score |
| Sep 17, 1988 | 8Notre Dame 20, Michigan State 3 | Box score |
| Sep 17, 1988 | 4Oklahoma 28, Arizona 10 | Box score |
| Sep 17, 1988 | Oregon 43, Washington State 28 | Box score |
| Sep 17, 1988 | Oregon State 17, California 16 | Box score |
| Sep 17, 1988 | 16Penn State 23, Boston College 20 | Box score |
| Sep 17, 1988 | Pittsburgh 42, 18Ohio State 10upset | Box score |
| Sep 17, 1988 | Purdue 33, Ohio 10 | Box score |
| Sep 17, 1988 | 14South Carolina 17, East Carolina 0 | Box score |
| Sep 17, 1988 | Southern Miss 35, Virginia Tech 13 | Box score |
| Sep 17, 1988 | Stanford 31, San Diego State 10 | Box score |
| Sep 17, 1988 | Temple 12, Navy 7 | Box score |
| Sep 17, 1988 | Texas 47, New Mexico 0 | Box score |
| Sep 17, 1988 | TCU 49, Bowling Green 12 | Box score |
| Sep 17, 1988 | Tulane 20, Kansas State 16 | Box score |
| Sep 17, 1988 | 2UCLA 56, Long Beach State 3 | Box score |
| Sep 17, 1988 | Vanderbilt 31, Rutgers 30 | Box score |
| Sep 17, 1988 | Virginia 17, Georgia Tech 16 | Box score |
| Sep 17, 1988 | 17Washington 31, Army 17 | Box score |
| Sep 17, 1988 | 12West Virginia 55, Maryland 24 | Box score |