| Sep 8, 1988 | BYU 47, 19Texas 6upset | Box score |
| Sep 8, 1988 | Wyoming 44, Louisville 9 | Box score |
| Sep 10, 1988 | 14Alabama 37, Temple 0 | Box score |
| Sep 10, 1988 | Arizona 35, Texas Tech 19 | Box score |
| Sep 10, 1988 | Arizona State 21, Illinois 16 | Box score |
| Sep 10, 1988 | Arkansas 30, Tulsa 26 | Box score |
| Sep 10, 1988 | 7Auburn 20, Kentucky 10 | Box score |
| Sep 10, 1988 | Ball State 34, Bowling Green 10 | Box score |
| Sep 10, 1988 | Baylor 27, Kansas 14 | Box score |
| Sep 10, 1988 | Boston College 41, Cincinnati 7 | Box score |
| Sep 10, 1988 | California 30, Pacific 7 | Box score |
| Sep 10, 1988 | Colorado 45, Fresno State 3 | Box score |
| Sep 10, 1988 | Duke 31, Tennessee 26upset | Box score |
| Sep 10, 1988 | Florida 27, Ole Miss 15 | Box score |
| Sep 10, 1988 | 10Florida State 49, Southern Miss 13 | Box score |
| Sep 10, 1988 | 8Georgia 38, TCU 10 | Box score |
| Sep 10, 1988 | Hawai’i 31, Colorado State 23 | Box score |
| Sep 10, 1988 | Indiana 41, Rice 14 | Box score |
| Sep 10, 1988 | 17Iowa 45, Kansas State 10 | Box score |
| Sep 10, 1988 | Iowa State 30, Tulane 13 | Box score |
| Sep 10, 1988 | Kent State 32, Akron 12 | Box score |
| Sep 10, 1988 | Missouri 35, Utah State 21 | Box score |
| Sep 10, 1988 | New Mexico 36, New Mexico State 34 | Box score |
| Sep 10, 1988 | 13Notre Dame 19, 9Michigan 17upset | Box score |
| Sep 10, 1988 | Ohio State 26, Syracuse 9 | Box score |
| Sep 10, 1988 | 4Oklahoma 28, North Carolina 0 | Box score |
| Sep 10, 1988 | Oklahoma State 52, Miami (OH) 20 | Box score |
| Sep 10, 1988 | Oregon 49, Long Beach State 0 | Box score |
| Sep 10, 1988 | Oregon State 41, San José State 27upset | Box score |
| Sep 10, 1988 | 18Penn State 42, Virginia 14 | Box score |
| Sep 10, 1988 | Rutgers 17, 15Michigan State 13upset | Box score |
| Sep 10, 1988 | 6USC 24, Stanford 20 | Box score |
| Sep 10, 1988 | 5UCLA 41, 2Nebraska 28upset | Box score |
| Sep 10, 1988 | Vanderbilt 24, Mississippi State 20 | Box score |
| Sep 10, 1988 | Virginia Tech 27, East Carolina 16 | Box score |
| Sep 10, 1988 | 20Washington 20, Purdue 6 | Box score |
| Sep 10, 1988 | Washington State 41, Minnesota 9 | Box score |
| Sep 10, 1988 | 12West Virginia 45, Cal State Fullerton 10 | Box score |
| Sep 10, 1988 | Western Michigan 31, Toledo 9 | Box score |
| Sep 11, 1988 | San Diego State 39, Air Force 36 | Box score |