| Oct 8, 1988 | Air Force 34, Navy 24 | Box score |
| Oct 8, 1988 | 20Arkansas 31, Texas Tech 10 | Box score |
| Oct 8, 1988 | Ball State 31, Kent State 20 | Box score |
| Oct 8, 1988 | Bowling Green 42, Ohio 0 | Box score |
| Oct 8, 1988 | BYU 42, Colorado State 7 | Box score |
| Oct 8, 1988 | Central Michigan 20, Eastern Michigan 6 | Box score |
| Oct 8, 1988 | 11Clemson 10, Virginia 7 | Box score |
| Oct 8, 1988 | Fresno State 23, Cal State Fullerton 10 | Box score |
| Oct 8, 1988 | 15Georgia 41, Vanderbilt 22 | Box score |
| Oct 8, 1988 | Illinois 20, Purdue 0 | Box score |
| Oct 8, 1988 | Indiana 41, Ohio State 7 | Box score |
| Oct 8, 1988 | Iowa 31, Wisconsin 6 | Box score |
| Oct 8, 1988 | LSU 7, 4Auburn 6upset | Box score |
| Oct 8, 1988 | Louisville 9, Tulsa 3 | Box score |
| Oct 8, 1988 | Maryland 13, Georgia Tech 8 | Box score |
| Oct 8, 1988 | Memphis 17, 14Florida 11upset | Box score |
| Oct 8, 1988 | 17Michigan 17, Michigan State 3 | Box score |
| Oct 8, 1988 | Ole Miss 22, 12Alabama 12upset | Box score |
| Oct 8, 1988 | Missouri 52, Kansas State 21 | Box score |
| Oct 8, 1988 | 9Nebraska 63, Kansas 10 | Box score |
| Oct 8, 1988 | UNLV 30, Pacific 16 | Box score |
| Oct 8, 1988 | Minnesota 28, Northwestern 28 | Box score |
| Oct 8, 1988 | 5Notre Dame 30, Pittsburgh 20 | Box score |
| Oct 8, 1988 | 10Oklahoma 28, Texas 13 | Box score |
| Oct 8, 1988 | 13Oklahoma State 41, Colorado 21 | Box score |
| Oct 8, 1988 | Penn State 35, Cincinnati 9 | Box score |
| Oct 8, 1988 | 8South Carolina 26, Virginia Tech 24 | Box score |
| Oct 8, 1988 | 3USC 42, 18Oregon 14 | Box score |
| Oct 8, 1988 | Southern Miss 38, Tulane 13 | Box score |
| Oct 8, 1988 | Stanford 44, San José State 12 | Box score |
| Oct 8, 1988 | Syracuse 34, Rutgers 20 | Box score |
| Oct 8, 1988 | Texas A&M 30, Houston 16 | Box score |
| Oct 8, 1988 | TCU 21, Rice 10 | Box score |
| Oct 8, 1988 | UTEP 42, Hawai’i 25 | Box score |
| Oct 8, 1988 | Toledo 33, Northern Illinois 20 | Box score |
| Oct 8, 1988 | 2UCLA 38, Oregon State 21 | Box score |
| Oct 8, 1988 | Utah 33, New Mexico 27 | Box score |
| Oct 8, 1988 | Utah State 31, Long Beach State 24 | Box score |
| Oct 8, 1988 | Wake Forest 42, North Carolina 24 | Box score |
| Oct 8, 1988 | 19Washington 10, Arizona State 0 | Box score |
| Oct 8, 1988 | Washington State 44, California 13 | Box score |
| Oct 8, 1988 | 7West Virginia 30, East Carolina 10 | Box score |
| Oct 8, 1988 | Western Michigan 41, Miami (OH) 18 | Box score |
| Oct 8, 1988 | 16Wyoming 55, San Diego State 27 | Box score |