| Sep 20, 1986 | 4Alabama 21, 13Florida 7 | Box score |
| Sep 20, 1986 | 17Arizona 41, Oregon 17 | Box score |
| Sep 20, 1986 | 18Arizona State 30, SMU 0 | Box score |
| Sep 20, 1986 | 12Arkansas 34, Tulsa 17 | Box score |
| Sep 20, 1986 | 10Auburn 45, East Carolina 0 | Box score |
| Sep 20, 1986 | California 31, Washington State 21 | Box score |
| Sep 20, 1986 | Central Michigan 20, Bowling Green 10 | Box score |
| Sep 20, 1986 | Clemson 31, 14Georgia 28upset | Box score |
| Sep 20, 1986 | Duke 22, Ohio 7 | Box score |
| Sep 20, 1986 | Georgia Tech 28, Virginia 14 | Box score |
| Sep 20, 1986 | Hawai’i 31, UTEP 21 | Box score |
| Sep 20, 1986 | Houston 28, Oklahoma State 12upset | Box score |
| Sep 20, 1986 | Indiana 52, Navy 29 | Box score |
| Sep 20, 1986 | Iowa 57, Northern Illinois 3 | Box score |
| Sep 20, 1986 | Kansas 16, Utah State 13 | Box score |
| Sep 20, 1986 | Kentucky 37, Kent State 12 | Box score |
| Sep 20, 1986 | Long Beach State 14, Western Michigan 13 | Box score |
| Sep 20, 1986 | Louisiana 26, Memphis 10 | Box score |
| Sep 20, 1986 | Maryland 24, West Virginia 3 | Box score |
| Sep 20, 1986 | Miami (OH) 21, 8LSU 12upset | Box score |
| Sep 20, 1986 | 3Michigan 31, Oregon State 12 | Box score |
| Sep 20, 1986 | Michigan State 20, 20Notre Dame 15upset | Box score |
| Sep 20, 1986 | 6Nebraska 59, Illinois 14 | Box score |
| Sep 20, 1986 | UNLV 17, Wisconsin 7 | Box score |
| Sep 20, 1986 | 15Florida State 10, North Carolina 10 | Box score |
| Sep 20, 1986 | NC State 42, Wake Forest 38 | Box score |
| Sep 20, 1986 | Northwestern 25, Army 18upset | Box score |
| Sep 20, 1986 | Ohio State 13, Colorado 10 | Box score |
| Sep 20, 1986 | 1Oklahoma 63, Minnesota 0 | Box score |
| Sep 20, 1986 | Pacific 41, New Mexico State 14 | Box score |
| Sep 20, 1986 | 5Penn State 26, Boston College 14 | Box score |
| Sep 20, 1986 | Pittsburgh 41, Purdue 26 | Box score |
| Sep 20, 1986 | Rutgers 48, Cincinnati 28 | Box score |
| Sep 20, 1986 | USC 17, 9Baylor 14upset | Box score |
| Sep 20, 1986 | Southern Miss 28, Mississippi State 24 | Box score |
| Sep 20, 1986 | Stanford 28, San José State 10 | Box score |
| Sep 20, 1986 | Texas 27, Missouri 25 | Box score |
| Sep 20, 1986 | TCU 35, Kansas State 22 | Box score |
| Sep 20, 1986 | Texas Tech 14, New Mexico 7 | Box score |
| Sep 20, 1986 | Tulane 35, Vanderbilt 17upset | Box score |
| Sep 20, 1986 | 19UCLA 45, San Diego State 14 | Box score |
| Sep 20, 1986 | Virginia Tech 26, Syracuse 17 | Box score |
| Sep 20, 1986 | 7Washington 52, 11BYU 21 | Box score |
| Sep 20, 1986 | Wyoming 23, Air Force 17upset | Box score |