| Sep 13, 1986 | 4Alabama 31, Southern Miss 17 | Box score |
| Sep 13, 1986 | Arizona 37, Colorado State 10 | Box score |
| Sep 13, 1986 | Arizona State 20, 20Michigan State 17upset | Box score |
| Sep 13, 1986 | 18Arkansas 21, Ole Miss 0 | Box score |
| Sep 13, 1986 | Army 33, Syracuse 28 | Box score |
| Sep 13, 1986 | Boston College 21, California 15 | Box score |
| Sep 13, 1986 | 11BYU 31, New Mexico 30 | Box score |
| Sep 13, 1986 | Cincinnati 45, Miami (OH) 38 | Box score |
| Sep 13, 1986 | Fresno State 27, Oregon State 0 | Box score |
| Sep 13, 1986 | 19Georgia 31, Duke 7 | Box score |
| Sep 13, 1986 | Indiana 21, Louisville 0 | Box score |
| Sep 13, 1986 | Iowa 43, Iowa State 7 | Box score |
| Sep 13, 1986 | 14LSU 35, 7Texas A&M 17upset | Box score |
| Sep 13, 1986 | Maryland 35, Vanderbilt 21 | Box score |
| Sep 13, 1986 | 2Miami 61, Texas Tech 11 | Box score |
| Sep 13, 1986 | 3Michigan 24, Notre Dame 23 | Box score |
| Sep 13, 1986 | Minnesota 31, Bowling Green 7 | Box score |
| Sep 13, 1986 | Mississippi State 27, 8Tennessee 23upset | Box score |
| Sep 13, 1986 | Missouri 24, Utah State 10 | Box score |
| Sep 13, 1986 | Navy 20, Virginia 10 | Box score |
| Sep 13, 1986 | North Carolina 20, Kansas 0 | Box score |
| Sep 13, 1986 | Oregon 32, Colorado 30 | Box score |
| Sep 13, 1986 | NC State 14, Pittsburgh 14 | Box score |
| Sep 13, 1986 | Purdue 20, Ball State 3 | Box score |
| Sep 13, 1986 | Kentucky 16, Rutgers 16 | Box score |
| Sep 13, 1986 | San Diego State 37, Utah 30 | Box score |
| Sep 13, 1986 | San José State 20, Washington State 13upset | Box score |
| Sep 13, 1986 | USC 31, Illinois 16 | Box score |
| Sep 13, 1986 | SMU 45, Rice 3 | Box score |
| Sep 13, 1986 | Stanford 31, Texas 20upset | Box score |
| Sep 13, 1986 | Temple 49, Western Michigan 17 | Box score |
| Sep 13, 1986 | TCU 48, Tulane 31 | Box score |
| Sep 13, 1986 | UTEP 47, New Mexico State 33 | Box score |
| Sep 13, 1986 | Toledo 30, Wichita State 13 | Box score |
| Sep 13, 1986 | Tulsa 27, Oklahoma State 23 | Box score |
| Sep 13, 1986 | Virginia Tech 20, Clemson 14 | Box score |
| Sep 13, 1986 | 17Washington 40, 10Ohio State 7upset | Box score |
| Sep 13, 1986 | West Virginia 24, East Carolina 21 | Box score |
| Sep 13, 1986 | Wisconsin 35, Northern Illinois 20 | Box score |
| Sep 13, 1986 | Wyoming 23, Pacific 20 | Box score |