| Sep 27, 1986 | Air Force 24, Colorado State 7 | Box score |
| Sep 27, 1986 | 10Arizona 24, Colorado 21 | Box score |
| Sep 27, 1986 | 9Arkansas 42, New Mexico State 11 | Box score |
| Sep 27, 1986 | 8Auburn 34, Tennessee 8 | Box score |
| Sep 27, 1986 | Ball State 27, Toledo 10 | Box score |
| Sep 27, 1986 | 17Baylor 45, Texas Tech 14 | Box score |
| Sep 27, 1986 | BYU 27, Temple 17 | Box score |
| Sep 27, 1986 | Central Michigan 56, Ohio 27 | Box score |
| Sep 27, 1986 | Clemson 27, Georgia Tech 3upset | Box score |
| Sep 27, 1986 | Duke 20, Virginia 13 | Box score |
| Sep 27, 1986 | Georgia 31, South Carolina 26 | Box score |
| Sep 27, 1986 | Indiana 41, Missouri 24 | Box score |
| Sep 27, 1986 | 15Iowa 69, UTEP 7 | Box score |
| Sep 27, 1986 | Iowa State 36, Wichita State 14 | Box score |
| Sep 27, 1986 | Kent State 20, Eastern Michigan 16upset | Box score |
| Sep 27, 1986 | Kentucky 37, Cincinnati 20 | Box score |
| Sep 27, 1986 | Louisville 34, Memphis 8 | Box score |
| Sep 27, 1986 | 2Miami 28, 1Oklahoma 16upset | Box score |
| Sep 27, 1986 | Miami (OH) 24, Bowling Green 7 | Box score |
| Sep 27, 1986 | 5Michigan 20, 20Florida State 18 | Box score |
| Sep 27, 1986 | 19Michigan State 45, Western Michigan 10 | Box score |
| Sep 27, 1986 | Ole Miss 35, Tulane 10 | Box score |
| Sep 27, 1986 | Mississippi State 16, Florida 10 | Box score |
| Sep 27, 1986 | 4Nebraska 48, Oregon 14 | Box score |
| Sep 27, 1986 | UNLV 40, Cal State Fullerton 23 | Box score |
| Sep 27, 1986 | NC State 28, 13Maryland 16upset | Box score |
| Sep 27, 1986 | Notre Dame 41, Purdue 9 | Box score |
| Sep 27, 1986 | Ohio State 64, Utah 6 | Box score |
| Sep 27, 1986 | Pacific 24, Minnesota 20upset | Box score |
| Sep 27, 1986 | 7Penn State 42, East Carolina 17 | Box score |
| Sep 27, 1986 | Pittsburgh 48, West Virginia 16 | Box score |
| Sep 27, 1986 | Rutgers 16, Syracuse 10 | Box score |
| Sep 27, 1986 | San Diego State 38, New Mexico 34 | Box score |
| Sep 27, 1986 | San José State 35, California 14 | Box score |
| Sep 27, 1986 | 12USC 20, 6Washington 10upset | Box score |
| Sep 27, 1986 | SMU 31, TCU 21 | Box score |
| Sep 27, 1986 | Stanford 17, Oregon State 7 | Box score |
| Sep 27, 1986 | 14Texas A&M 16, Southern Miss 7 | Box score |
| Sep 27, 1986 | Tulsa 24, Houston 14 | Box score |
| Sep 27, 1986 | 16UCLA 41, Long Beach State 23 | Box score |
| Sep 27, 1986 | Wake Forest 49, Army 14upset | Box score |
| Sep 27, 1986 | 11Arizona State 21, Washington State 21 | Box score |
| Sep 27, 1986 | Wyoming 21, Wisconsin 12 | Box score |