| Oct 19, 1985 | 10Air Force 35, Colorado State 19 | Box score |
| Oct 19, 1985 | Arizona 41, San José State 0 | Box score |
| Oct 19, 1985 | Arizona State 42, Utah State 10 | Box score |
| Oct 19, 1985 | 8Auburn 17, Georgia Tech 14 | Box score |
| Oct 19, 1985 | 14Baylor 20, Texas A&M 15 | Box score |
| Oct 19, 1985 | Bowling Green 23, Central Michigan 18 | Box score |
| Oct 19, 1985 | 9BYU 45, New Mexico 23 | Box score |
| Oct 19, 1985 | California 27, Oregon 24 | Box score |
| Oct 19, 1985 | Cincinnati 31, Louisville 9 | Box score |
| Oct 19, 1985 | Clemson 21, Duke 9 | Box score |
| Oct 19, 1985 | Colorado 40, Iowa State 6 | Box score |
| Oct 19, 1985 | Eastern Michigan 27, Ohio 21 | Box score |
| Oct 19, 1985 | 5Florida 45, Louisiana 0 | Box score |
| Oct 19, 1985 | 13Florida State 76, Tulsa 14 | Box score |
| Oct 19, 1985 | Fresno State 48, New Mexico State 21 | Box score |
| Oct 19, 1985 | Vanderbilt 13, 16Georgia 13 | Box score |
| Oct 19, 1985 | Illinois 30, Michigan State 17 | Box score |
| Oct 19, 1985 | 1Iowa 12, 2Michigan 10 | Box score |
| Oct 19, 1985 | Kansas 38, Kansas State 7 | Box score |
| Oct 19, 1985 | Kent State 45, Ball State 16 | Box score |
| Oct 19, 1985 | 17LSU 10, Kentucky 0 | Box score |
| Oct 19, 1985 | Maryland 26, Wake Forest 3 | Box score |
| Oct 19, 1985 | Miami 27, 3Oklahoma 14upset | Box score |
| Oct 19, 1985 | Minnesota 22, Indiana 7 | Box score |
| Oct 19, 1985 | Mississippi State 31, Tulane 27 | Box score |
| Oct 19, 1985 | 7Nebraska 28, Missouri 20 | Box score |
| Oct 19, 1985 | UNLV 10, Cal State Fullerton 6 | Box score |
| Oct 19, 1985 | North Carolina 21, NC State 14 | Box score |
| Oct 19, 1985 | Northern Illinois 16, Toledo 3 | Box score |
| Oct 19, 1985 | Northwestern 17, Wisconsin 14upset | Box score |
| Oct 19, 1985 | Notre Dame 24, 19Army 10upset | Box score |
| Oct 19, 1985 | 11Ohio State 41, Purdue 27 | Box score |
| Oct 19, 1985 | Oregon State 21, Washington 20upset | Box score |
| Oct 19, 1985 | Pacific 24, Hawai’i 15upset | Box score |
| Oct 19, 1985 | 6Penn State 24, Syracuse 20 | Box score |
| Oct 19, 1985 | Pittsburgh 38, Rutgers 10 | Box score |
| Oct 19, 1985 | Rice 29, Texas Tech 27upset | Box score |
| Oct 19, 1985 | South Carolina 52, East Carolina 10 | Box score |
| Oct 19, 1985 | USC 30, Stanford 6 | Box score |
| Oct 19, 1985 | SMU 37, Houston 13 | Box score |
| Oct 19, 1985 | Southern Miss 14, Memphis 7 | Box score |
| Oct 19, 1985 | 20Tennessee 16, 15Alabama 14upset | Box score |
| Oct 19, 1985 | Texas 15, 4Arkansas 13upset | Box score |
| Oct 19, 1985 | 18UCLA 31, Washington State 30 | Box score |
| Oct 19, 1985 | Utah 39, San Diego State 37 | Box score |
| Oct 19, 1985 | Virginia Tech 28, Virginia 10upset | Box score |
| Oct 19, 1985 | West Virginia 13, Boston College 6 | Box score |
| Oct 19, 1985 | Miami (OH) 10, Western Michigan 10 | Box score |