| Oct 12, 1985 | 13Air Force 24, Navy 7 | Box score |
| Oct 12, 1985 | Arizona State 34, Utah 27 | Box score |
| Oct 12, 1985 | 6Arkansas 30, Texas Tech 7 | Box score |
| Oct 12, 1985 | Army 45, Boston College 14 | Box score |
| Oct 12, 1985 | 12Auburn 59, 4Florida State 27upset | Box score |
| Oct 12, 1985 | Ball State 36, Ohio 23 | Box score |
| Oct 12, 1985 | 19Baylor 21, 16SMU 14upset | Box score |
| Oct 12, 1985 | Bowling Green 42, Eastern Michigan 24 | Box score |
| Oct 12, 1985 | 11BYU 28, San Diego State 0 | Box score |
| Oct 12, 1985 | Cal State Fullerton 32, Utah State 30 | Box score |
| Oct 12, 1985 | Central Michigan 24, Western Michigan 17 | Box score |
| Oct 12, 1985 | Clemson 27, Virginia 24 | Box score |
| Oct 12, 1985 | Colorado 38, Missouri 7 | Box score |
| Oct 12, 1985 | Colorado State 45, New Mexico 28 | Box score |
| Oct 12, 1985 | 7Florida 17, 14Tennessee 10 | Box score |
| Oct 12, 1985 | Fresno State 37, San José State 17 | Box score |
| Oct 12, 1985 | 18Georgia 49, Ole Miss 21 | Box score |
| Oct 12, 1985 | Hawai’i 26, Wyoming 18 | Box score |
| Oct 12, 1985 | 1Iowa 23, Wisconsin 13 | Box score |
| Oct 12, 1985 | Iowa State 22, Kansas 21 | Box score |
| Oct 12, 1985 | Kent State 51, UTEP 24 | Box score |
| Oct 12, 1985 | Kentucky 33, Mississippi State 19 | Box score |
| Oct 12, 1985 | Louisiana 16, East Carolina 14 | Box score |
| Oct 12, 1985 | 20LSU 49, Vanderbilt 7 | Box score |
| Oct 12, 1985 | Memphis 38, Tulane 21 | Box score |
| Oct 12, 1985 | Miami 38, Cincinnati 0 | Box score |
| Oct 12, 1985 | Miami (OH) 26, Toledo 14 | Box score |
| Oct 12, 1985 | 3Michigan 31, Michigan State 0 | Box score |
| Oct 12, 1985 | Minnesota 21, Northwestern 10 | Box score |
| Oct 12, 1985 | 9Nebraska 34, 5Oklahoma State 24upset | Box score |
| Oct 12, 1985 | UNLV 24, Pacific 14 | Box score |
| Oct 12, 1985 | North Carolina 34, Wake Forest 14 | Box score |
| Oct 12, 1985 | 15Ohio State 48, Indiana 7 | Box score |
| Oct 12, 1985 | 2Oklahoma 14, 17Texas 7 | Box score |
| Oct 12, 1985 | 8Penn State 19, 10Alabama 17 | Box score |
| Oct 12, 1985 | Pittsburgh 24, NC State 10 | Box score |
| Oct 12, 1985 | Purdue 30, Illinois 24 | Box score |
| Oct 12, 1985 | Rice 34, TCU 27 | Box score |
| Oct 12, 1985 | South Carolina 28, Duke 7 | Box score |
| Oct 12, 1985 | Southern Miss 42, Louisville 12 | Box score |
| Oct 12, 1985 | Temple 14, Rutgers 13 | Box score |
| Oct 12, 1985 | Texas A&M 43, Houston 16 | Box score |
| Oct 12, 1985 | Tulsa 37, Long Beach State 35 | Box score |
| Oct 12, 1985 | UCLA 34, Stanford 9 | Box score |
| Oct 12, 1985 | Washington 28, California 12 | Box score |
| Oct 12, 1985 | Washington State 34, Oregon State 0 | Box score |
| Oct 12, 1985 | West Texas 33, Wichita State 21 | Box score |