| Oct 26, 1985 | 8Air Force 37, Utah 15 | Box score |
| Oct 26, 1985 | Alabama 28, Memphis 9 | Box score |
| Oct 26, 1985 | Arizona State 21, Washington State 16 | Box score |
| Oct 26, 1985 | 14Arkansas 57, Houston 27 | Box score |
| Oct 26, 1985 | 6Auburn 21, Mississippi State 9 | Box score |
| Oct 26, 1985 | 13Baylor 45, TCU 0 | Box score |
| Oct 26, 1985 | Bowling Green 26, Kent State 14 | Box score |
| Oct 26, 1985 | Central Michigan 17, Eastern Michigan 10 | Box score |
| Oct 26, 1985 | Cincinnati 24, Boston College 17 | Box score |
| Oct 26, 1985 | Clemson 39, NC State 10 | Box score |
| Oct 26, 1985 | Colorado State 30, Wyoming 19 | Box score |
| Oct 26, 1985 | 2Florida 35, Virginia Tech 18 | Box score |
| Oct 26, 1985 | 11Florida State 20, North Carolina 10 | Box score |
| Oct 26, 1985 | Fresno State 38, Utah State 19 | Box score |
| Oct 26, 1985 | Georgia 26, Kentucky 6 | Box score |
| Oct 26, 1985 | 16Tennessee 6, Georgia Tech 6 | Box score |
| Oct 26, 1985 | Hawai’i 27, New Mexico 17 | Box score |
| Oct 26, 1985 | Illinois 38, Wisconsin 25 | Box score |
| Oct 26, 1985 | 1Iowa 49, Northwestern 10 | Box score |
| Oct 26, 1985 | Kansas State 20, Missouri 17upset | Box score |
| Oct 26, 1985 | Long Beach State 38, New Mexico State 17 | Box score |
| Oct 26, 1985 | Louisiana 20, UNLV 13 | Box score |
| Oct 26, 1985 | Maryland 40, Duke 10 | Box score |
| Oct 26, 1985 | 15Miami 45, Louisville 7 | Box score |
| Oct 26, 1985 | Miami (OH) 32, Northern Illinois 15 | Box score |
| Oct 26, 1985 | 4Michigan 42, Indiana 15 | Box score |
| Oct 26, 1985 | Michigan State 28, Purdue 24upset | Box score |
| Oct 26, 1985 | Ole Miss 35, Vanderbilt 7 | Box score |
| Oct 26, 1985 | Navy 21, Pittsburgh 7 | Box score |
| Oct 26, 1985 | 5Nebraska 17, Colorado 7 | Box score |
| Oct 26, 1985 | Notre Dame 37, USC 3 | Box score |
| Oct 26, 1985 | 9Ohio State 23, 20Minnesota 19 | Box score |
| Oct 26, 1985 | 10Oklahoma 59, Iowa State 14 | Box score |
| Oct 26, 1985 | 12Oklahoma State 17, Kansas 10 | Box score |
| Oct 26, 1985 | Oregon 49, San Diego State 37 | Box score |
| Oct 26, 1985 | 3Penn State 27, West Virginia 0 | Box score |
| Oct 26, 1985 | San José State 34, Pacific 26 | Box score |
| Oct 26, 1985 | SMU 44, 19Texas 14upset | Box score |
| Oct 26, 1985 | Stanford 28, Arizona 17upset | Box score |
| Oct 26, 1985 | Syracuse 29, Temple 14 | Box score |
| Oct 26, 1985 | Texas A&M 43, Rice 28 | Box score |
| Oct 26, 1985 | UTEP 23, 7BYU 16upset | Box score |
| Oct 26, 1985 | Toledo 24, Ohio 10 | Box score |
| Oct 26, 1985 | Tulsa 44, West Texas 17 | Box score |
| Oct 26, 1985 | 17UCLA 34, California 7 | Box score |
| Oct 26, 1985 | Virginia 20, Wake Forest 18 | Box score |
| Oct 26, 1985 | Western Michigan 34, Ball State 0 | Box score |