| Oct 31, 1981 | Air Force 7, Army 3 | Box score |
| Oct 31, 1981 | 8Alabama 13, 7Mississippi State 10upset | Box score |
| Oct 31, 1981 | Arizona 48, UTEP 15 | Box score |
| Oct 31, 1981 | 10Arizona State 31, San José State 24 | Box score |
| Oct 31, 1981 | 20Arkansas 41, Rice 7 | Box score |
| Oct 31, 1981 | Arkansas State 10, Texas–Arlington 7 | Box score |
| Oct 31, 1981 | Auburn 14, Florida 12 | Box score |
| Oct 31, 1981 | Ball State 35, Eastern Michigan 13 | Box score |
| Oct 31, 1981 | Bowling Green 13, Kent State 7 | Box score |
| Oct 31, 1981 | BYU 31, New Mexico 7 | Box score |
| Oct 31, 1981 | California 45, Oregon State 3 | Box score |
| Oct 31, 1981 | Central Michigan 38, Ohio 21 | Box score |
| Oct 31, 1981 | Cincinnati 17, Tulane 13 | Box score |
| Oct 31, 1981 | 3Clemson 82, Wake Forest 24 | Box score |
| Oct 31, 1981 | Duke 38, Georgia Tech 24 | Box score |
| Oct 31, 1981 | 17Florida State 56, Western Carolina 31 | Box score |
| Oct 31, 1981 | Furman 35, Marshall 3 | Box score |
| Oct 31, 1981 | 5Georgia 49, Temple 3 | Box score |
| Oct 31, 1981 | Harvard 41, Brown 7 | Box score |
| Oct 31, 1981 | Hawai’i 57, UNLV 21 | Box score |
| Oct 31, 1981 | Holy Cross 14, Columbia 7 | Box score |
| Oct 31, 1981 | Houston 20, TCU 16 | Box score |
| Oct 31, 1981 | Illinois 24, 16Iowa 7upset | Box score |
| Oct 31, 1981 | Kansas State 10, 11Iowa State 7upset | Box score |
| Oct 31, 1981 | LSU 27, Ole Miss 27 | Box score |
| Oct 31, 1981 | Louisiana Tech 17, Louisiana 17 | Box score |
| Oct 31, 1981 | McNeese 20, Lamar 20 | Box score |
| Oct 31, 1981 | Miami 17, 1Penn State 14upset | Box score |
| Oct 31, 1981 | 15Michigan 34, Minnesota 13 | Box score |
| Oct 31, 1981 | Michigan State 26, Indiana 3 | Box score |
| Oct 31, 1981 | 12Nebraska 31, Kansas 15 | Box score |
| Oct 31, 1981 | 9North Carolina 17, Maryland 10 | Box score |
| Oct 31, 1981 | Notre Dame 38, Navy 0 | Box score |
| Oct 31, 1981 | Ohio State 45, Purdue 33 | Box score |
| Oct 31, 1981 | 19Oklahoma 49, Colorado 0 | Box score |
| Oct 31, 1981 | Oklahoma State 16, Missouri 12upset | Box score |
| Oct 31, 1981 | Pacific 17, Cal State Fullerton 16 | Box score |
| Oct 31, 1981 | 2Pittsburgh 29, Boston College 24 | Box score |
| Oct 31, 1981 | Princeton 38, Pennsylvania 30 | Box score |
| Oct 31, 1981 | South Carolina 20, NC State 12 | Box score |
| Oct 31, 1981 | 4USC 41, 14Washington State 17 | Box score |
| Oct 31, 1981 | Southern Illinois 17, Indiana State 3 | Box score |
| Oct 31, 1981 | 13SMU 27, Texas A&M 7 | Box score |
| Oct 31, 1981 | Southern Miss 22, North Texas 0 | Box score |
| Oct 31, 1981 | Syracuse 47, Colgate 24 | Box score |
| Oct 31, 1981 | 6Texas 26, Texas Tech 9 | Box score |
| Oct 31, 1981 | Toledo 17, Miami (OH) 10 | Box score |
| Oct 31, 1981 | Tulsa 59, Drake 6 | Box score |
| Oct 31, 1981 | UCLA 28, Oregon 11 | Box score |
| Oct 31, 1981 | Utah 17, San Diego State 14 | Box score |
| Oct 31, 1981 | Utah State 20, Fresno State 0 | Box score |
| Oct 31, 1981 | Vanderbilt 26, Memphis 0 | Box score |
| Oct 31, 1981 | Virginia 13, VMI 10 | Box score |
| Oct 31, 1981 | Virginia Tech 29, Kentucky 3 | Box score |
| Oct 31, 1981 | 18Washington 42, Stanford 31 | Box score |
| Oct 31, 1981 | West Virginia 20, East Carolina 3 | Box score |
| Oct 31, 1981 | Western Michigan 23, Northern Illinois 12 | Box score |
| Oct 31, 1981 | Wichita State 38, Illinois State 7 | Box score |
| Oct 31, 1981 | Wisconsin 52, Northwestern 0 | Box score |
| Oct 31, 1981 | Wyoming 55, Colorado State 21 | Box score |
| Oct 31, 1981 | Yale 24, Dartmouth 3 | Box score |