| Nov 7, 1981 | 19Arkansas 41, Baylor 39 | Box score |
| Nov 7, 1981 | Arkansas State 16, Lamar 9 | Box score |
| Nov 7, 1981 | Auburn 20, North Texas 0 | Box score |
| Nov 7, 1981 | Bowling Green 14, Ball State 10 | Box score |
| Nov 7, 1981 | BYU 63, Colorado State 14 | Box score |
| Nov 7, 1981 | Cincinnati 38, Memphis 7 | Box score |
| Nov 7, 1981 | Chattanooga 28, The Citadel 28 | Box score |
| Nov 7, 1981 | 2Clemson 10, 8North Carolina 8 | Box score |
| Nov 7, 1981 | Dartmouth 21, Columbia 7 | Box score |
| Nov 7, 1981 | Drake 22, Southern Illinois 17 | Box score |
| Nov 7, 1981 | Duke 31, Wake Forest 10 | Box score |
| Nov 7, 1981 | Fresno State 42, UNLV 26 | Box score |
| Nov 7, 1981 | 4Georgia 26, Florida 21 | Box score |
| Nov 7, 1981 | Harvard 23, William & Mary 14 | Box score |
| Nov 7, 1981 | Hawai’i 35, UTEP 7 | Box score |
| Nov 7, 1981 | Holy Cross 28, Army 13 | Box score |
| Nov 7, 1981 | Iowa 33, Purdue 7 | Box score |
| Nov 7, 1981 | Kansas 24, Iowa State 11 | Box score |
| Nov 7, 1981 | Kent State 13, Eastern Michigan 7 | Box score |
| Nov 7, 1981 | Kentucky 17, Vanderbilt 10 | Box score |
| Nov 7, 1981 | UL Monroe 40, Louisville 7 | Box score |
| Nov 7, 1981 | Marshall 17, App State 10upset | Box score |
| Nov 7, 1981 | McNeese 27, Louisiana Tech 20 | Box score |
| Nov 7, 1981 | 13Miami 27, 14Florida State 19 | Box score |
| Nov 7, 1981 | Miami (OH) 7, Central Michigan 3 | Box score |
| Nov 7, 1981 | 12Michigan 70, Illinois 21 | Box score |
| Nov 7, 1981 | Michigan State 61, Northwestern 14 | Box score |
| Nov 7, 1981 | Minnesota 35, 18Ohio State 31upset | Box score |
| Nov 7, 1981 | Missouri 30, Colorado 14 | Box score |
| Nov 7, 1981 | Navy 35, Syracuse 23 | Box score |
| Nov 7, 1981 | 11Nebraska 54, Oklahoma State 7 | Box score |
| Nov 7, 1981 | Northern Illinois 38, Ohio 14 | Box score |
| Nov 7, 1981 | Notre Dame 35, Georgia Tech 3 | Box score |
| Nov 7, 1981 | 17Oklahoma 28, Kansas State 21 | Box score |
| Nov 7, 1981 | Pacific 23, South Carolina 21upset | Box score |
| Nov 7, 1981 | 6Penn State 22, NC State 15 | Box score |
| Nov 7, 1981 | 1Pittsburgh 47, Rutgers 3 | Box score |
| Nov 7, 1981 | Richmond 45, VMI 14upset | Box score |
| Nov 7, 1981 | 3USC 21, California 3 | Box score |
| Nov 7, 1981 | 10SMU 33, Rice 12 | Box score |
| Nov 7, 1981 | 20Southern Miss 7, 15Mississippi State 6upset | Box score |
| Nov 7, 1981 | Stanford 63, Oregon State 9 | Box score |
| Nov 7, 1981 | Tennessee 24, Wichita State 21 | Box score |
| Nov 7, 1981 | Houston 14, 5Texas 14 | Box score |
| Nov 7, 1981 | Texas Tech 39, TCU 39 | Box score |
| Nov 7, 1981 | Texas–Arlington 23, Louisiana 7 | Box score |
| Nov 7, 1981 | Toledo 28, Western Michigan 14 | Box score |
| Nov 7, 1981 | Tulane 14, Maryland 7 | Box score |
| Nov 7, 1981 | Tulsa 31, New Mexico State 0 | Box score |
| Nov 7, 1981 | UCLA 31, 16Washington 0upset | Box score |
| Nov 7, 1981 | New Mexico 7, Utah 7 | Box score |
| Nov 7, 1981 | Utah State 28, Long Beach State 2 | Box score |
| Nov 7, 1981 | Washington State 39, Oregon 7 | Box score |
| Nov 7, 1981 | West Texas 17, Indiana State 14 | Box score |
| Nov 7, 1981 | West Virginia 24, Temple 19 | Box score |
| Nov 7, 1981 | Wisconsin 28, Indiana 7 | Box score |
| Nov 7, 1981 | Wyoming 24, San Diego State 13 | Box score |
| Nov 7, 1981 | Yale 23, Cornell 17 | Box score |