| Nov 14, 1981 | 6Alabama 31, 5Penn State 16upset | Box score |
| Nov 14, 1981 | Arizona 40, Oregon State 7 | Box score |
| Nov 14, 1981 | 16Arkansas 10, Texas A&M 7 | Box score |
| Nov 14, 1981 | Bowling Green 28, Eastern Michigan 0 | Box score |
| Nov 14, 1981 | BYU 13, 19Hawai’i 3upset | Box score |
| Nov 14, 1981 | Central Michigan 28, Ball State 7 | Box score |
| Nov 14, 1981 | Cincinnati 24, Louisville 0 | Box score |
| Nov 14, 1981 | 2Clemson 21, Maryland 7 | Box score |
| Nov 14, 1981 | Colgate 32, Holy Cross 13 | Box score |
| Nov 14, 1981 | Cornell 15, Columbia 9 | Box score |
| Nov 14, 1981 | Dartmouth 38, Brown 13 | Box score |
| Nov 14, 1981 | Drake 13, Illinois State 10 | Box score |
| Nov 14, 1981 | Duke 17, NC State 7 | Box score |
| Nov 14, 1981 | Florida 33, Kentucky 12 | Box score |
| Nov 14, 1981 | Fresno State 31, Long Beach State 30 | Box score |
| Nov 14, 1981 | Furman 33, VMI 21 | Box score |
| Nov 14, 1981 | 4Georgia 24, Auburn 13 | Box score |
| Nov 14, 1981 | Harvard 45, Pennsylvania 7 | Box score |
| Nov 14, 1981 | Illinois 35, Indiana 14 | Box score |
| Nov 14, 1981 | Iowa 17, Wisconsin 7 | Box score |
| Nov 14, 1981 | Kansas 27, Colorado 0 | Box score |
| Nov 14, 1981 | Lamar 14, Louisiana 12 | Box score |
| Nov 14, 1981 | Louisiana Tech 32, Arkansas State 0 | Box score |
| Nov 14, 1981 | 12Miami 21, Virginia Tech 14 | Box score |
| Nov 14, 1981 | Miami (OH) 30, Northern Illinois 3 | Box score |
| Nov 14, 1981 | 11Michigan 28, Purdue 10 | Box score |
| Nov 14, 1981 | Michigan State 43, Minnesota 36 | Box score |
| Nov 14, 1981 | Mississippi State 17, LSU 9 | Box score |
| Nov 14, 1981 | Missouri 19, 15Oklahoma 14upset | Box score |
| Nov 14, 1981 | Navy 20, Georgia Tech 14 | Box score |
| Nov 14, 1981 | 7Nebraska 31, Iowa State 7 | Box score |
| Nov 14, 1981 | New Mexico 28, Colorado State 16 | Box score |
| Nov 14, 1981 | 13North Carolina 17, Virginia 14 | Box score |
| Nov 14, 1981 | North Texas 17, UL Monroe 14upset | Box score |
| Nov 14, 1981 | Notre Dame 35, Air Force 7 | Box score |
| Nov 14, 1981 | Ohio 37, Western Michigan 20 | Box score |
| Nov 14, 1981 | Ohio State 70, Northwestern 6 | Box score |
| Nov 14, 1981 | Oklahoma State 31, Kansas State 10 | Box score |
| Nov 14, 1981 | 1Pittsburgh 48, Army 0 | Box score |
| Nov 14, 1981 | Princeton 35, Yale 31upset | Box score |
| Nov 14, 1981 | Rice 17, Baylor 14upset | Box score |
| Nov 14, 1981 | San Diego State 38, UNLV 20 | Box score |
| Nov 14, 1981 | San José State 40, Pacific 25 | Box score |
| Nov 14, 1981 | Southern Illinois 23, New Mexico State 15 | Box score |
| Nov 14, 1981 | 8SMU 30, Texas Tech 6 | Box score |
| Nov 14, 1981 | 14Southern Miss 58, 20Florida State 14 | Box score |
| Nov 14, 1981 | Stanford 42, Oregon 3 | Box score |
| Nov 14, 1981 | Syracuse 27, Boston College 17 | Box score |
| Nov 14, 1981 | Tennessee 28, Ole Miss 20 | Box score |
| Nov 14, 1981 | 10Texas 31, TCU 15 | Box score |
| Nov 14, 1981 | Texas–Arlington 21, McNeese 20upset | Box score |
| Nov 14, 1981 | Toledo 17, Kent State 0 | Box score |
| Nov 14, 1981 | Tulane 24, Memphis 7 | Box score |
| Nov 14, 1981 | Tulsa 24, West Texas 10 | Box score |
| Nov 14, 1981 | 18UCLA 34, 9Arizona State 24upset | Box score |
| Nov 14, 1981 | Utah 30, Wyoming 27 | Box score |
| Nov 14, 1981 | Wake Forest 34, Richmond 22 | Box score |
| Nov 14, 1981 | Washington 13, 3USC 3upset | Box score |
| Nov 14, 1981 | 17Washington State 19, California 0 | Box score |
| Nov 14, 1981 | West Virginia 20, Rutgers 3 | Box score |
| Nov 14, 1981 | Western Carolina 38, Marshall 28 | Box score |
| Nov 14, 1981 | William & Mary 31, East Carolina 21upset | Box score |