| Nov 21, 1981 | 20Arizona State 52, Colorado State 7 | Box score |
| Nov 21, 1981 | Arkansas State 31, Tulsa 7upset | Box score |
| Nov 21, 1981 | Ball State 14, Illinois State 10 | Box score |
| Nov 21, 1981 | Boston College 27, Rutgers 21 | Box score |
| Nov 21, 1981 | 18BYU 56, Utah 28 | Box score |
| Nov 21, 1981 | Brown 23, Columbia 20 | Box score |
| Nov 21, 1981 | Central Michigan 6, Bowling Green 3 | Box score |
| Nov 21, 1981 | The Citadel 35, Furman 18 | Box score |
| Nov 21, 1981 | 2Clemson 29, South Carolina 13 | Box score |
| Nov 21, 1981 | Colorado 24, Kansas State 21 | Box score |
| Nov 21, 1981 | Dartmouth 33, Pennsylvania 13 | Box score |
| Nov 21, 1981 | Fresno State 23, Arizona 17upset | Box score |
| Nov 21, 1981 | Houston 15, Texas Tech 7 | Box score |
| Nov 21, 1981 | Illinois 49, Northwestern 12 | Box score |
| Nov 21, 1981 | Indiana 20, Purdue 17upset | Box score |
| Nov 21, 1981 | Indiana State 42, Marshall 0 | Box score |
| Nov 21, 1981 | 19Iowa 36, Michigan State 7 | Box score |
| Nov 21, 1981 | Kansas 19, Missouri 11 | Box score |
| Nov 21, 1981 | Kentucky 21, Tennessee 10upset | Box score |
| Nov 21, 1981 | Louisville 13, 9Southern Miss 10upset | Box score |
| Nov 21, 1981 | Maryland 48, Virginia 7 | Box score |
| Nov 21, 1981 | McNeese 14, Louisiana 7 | Box score |
| Nov 21, 1981 | 11Miami 14, NC State 6 | Box score |
| Nov 21, 1981 | Miami (OH) 7, Cincinnati 3 | Box score |
| Nov 21, 1981 | Ole Miss 21, Mississippi State 17upset | Box score |
| Nov 21, 1981 | 5Nebraska 37, Oklahoma 14 | Box score |
| Nov 21, 1981 | UNLV 24, Air Force 21 | Box score |
| Nov 21, 1981 | 12North Carolina 31, Duke 10 | Box score |
| Nov 21, 1981 | Ohio 20, Kent State 7 | Box score |
| Nov 21, 1981 | Ohio State 14, 7Michigan 9upset | Box score |
| Nov 21, 1981 | Oklahoma State 27, Iowa State 7 | Box score |
| Nov 21, 1981 | Oregon 47, Oregon State 17 | Box score |
| Nov 21, 1981 | Pacific 23, Hawai’i 17upset | Box score |
| Nov 21, 1981 | 13Penn State 24, Notre Dame 21 | Box score |
| Nov 21, 1981 | 1Pittsburgh 35, Temple 0 | Box score |
| Nov 21, 1981 | Princeton 37, Cornell 14 | Box score |
| Nov 21, 1981 | San Diego State 59, UTEP 14 | Box score |
| Nov 21, 1981 | San José State 24, Long Beach State 22 | Box score |
| Nov 21, 1981 | 10USC 22, 15UCLA 21 | Box score |
| Nov 21, 1981 | 6SMU 32, 16Arkansas 18 | Box score |
| Nov 21, 1981 | Stanford 42, California 21 | Box score |
| Nov 21, 1981 | Syracuse 27, West Virginia 24 | Box score |
| Nov 21, 1981 | 8Texas 34, Baylor 12 | Box score |
| Nov 21, 1981 | Texas A&M 37, TCU 7 | Box score |
| Nov 21, 1981 | Texas–Arlington 31, Lamar 7 | Box score |
| Nov 21, 1981 | Toledo 31, Northern Illinois 0 | Box score |
| Nov 21, 1981 | Vanderbilt 28, Chattanooga 14upset | Box score |
| Nov 21, 1981 | VMI 6, Virginia Tech 0upset | Box score |
| Nov 21, 1981 | 17Washington 23, 14Washington State 10upset | Box score |
| Nov 21, 1981 | West Texas 45, New Mexico State 9 | Box score |
| Nov 21, 1981 | Western Carolina 21, App State 10 | Box score |
| Nov 21, 1981 | Western Michigan 38, Eastern Michigan 7 | Box score |
| Nov 21, 1981 | William & Mary 35, Richmond 21 | Box score |
| Nov 21, 1981 | Wisconsin 26, Minnesota 21 | Box score |
| Nov 21, 1981 | Wyoming 13, New Mexico 12 | Box score |
| Nov 21, 1981 | Yale 28, Harvard 0 | Box score |