| Oct 24, 1981 | Air Force 20, Oregon 10upset | Box score |
| Oct 24, 1981 | 11Alabama 31, Rutgers 7 | Box score |
| Oct 24, 1981 | 17Arizona State 62, Stanford 36 | Box score |
| Oct 24, 1981 | Baylor 34, TCU 21 | Box score |
| Oct 24, 1981 | Boston College 41, Army 6 | Box score |
| Oct 24, 1981 | Bowling Green 38, Toledo 0 | Box score |
| Oct 24, 1981 | Central Michigan 24, Kent State 3 | Box score |
| Oct 24, 1981 | 4Clemson 17, NC State 7 | Box score |
| Oct 24, 1981 | Colgate 41, Columbia 3 | Box score |
| Oct 24, 1981 | Dartmouth 42, Cornell 7 | Box score |
| Oct 24, 1981 | Drake 21, West Texas 13 | Box score |
| Oct 24, 1981 | 20Florida State 38, LSU 14 | Box score |
| Oct 24, 1981 | Fresno State 30, Pacific 27 | Box score |
| Oct 24, 1981 | 7Georgia 21, Kentucky 0 | Box score |
| Oct 24, 1981 | Hawai’i 28, San Diego State 10 | Box score |
| Oct 24, 1981 | Holy Cross 34, Brown 24 | Box score |
| Oct 24, 1981 | Houston 20, 12Arkansas 17upset | Box score |
| Oct 24, 1981 | Illinois 23, Wisconsin 21 | Box score |
| Oct 24, 1981 | Indiana State 34, Illinois State 14 | Box score |
| Oct 24, 1981 | 14Iowa State 17, Colorado 10 | Box score |
| Oct 24, 1981 | Kansas 17, Kansas State 14 | Box score |
| Oct 24, 1981 | Long Beach State 10, Cal State Fullerton 9 | Box score |
| Oct 24, 1981 | Maryland 24, Duke 21 | Box score |
| Oct 24, 1981 | McNeese 21, Arkansas State 7 | Box score |
| Oct 24, 1981 | Miami 31, East Carolina 6 | Box score |
| Oct 24, 1981 | Miami (OH) 40, Ohio 14 | Box score |
| Oct 24, 1981 | 18Michigan 38, Northwestern 0 | Box score |
| Oct 24, 1981 | Minnesota 12, 6Iowa 10upset | Box score |
| Oct 24, 1981 | 9Mississippi State 21, Auburn 17 | Box score |
| Oct 24, 1981 | Navy 27, William & Mary 0 | Box score |
| Oct 24, 1981 | 15Nebraska 6, 19Missouri 0 | Box score |
| Oct 24, 1981 | New Mexico 17, New Mexico State 13 | Box score |
| Oct 24, 1981 | Northern Illinois 30, Eastern Michigan 7 | Box score |
| Oct 24, 1981 | Ohio State 29, Indiana 10 | Box score |
| Oct 24, 1981 | Oklahoma 42, Oregon State 3 | Box score |
| Oct 24, 1981 | Oklahoma State 19, Louisville 11 | Box score |
| Oct 24, 1981 | 1Penn State 30, West Virginia 7 | Box score |
| Oct 24, 1981 | 2Pittsburgh 23, Syracuse 10 | Box score |
| Oct 24, 1981 | Harvard 17, Princeton 17 | Box score |
| Oct 24, 1981 | Purdue 27, Michigan State 26 | Box score |
| Oct 24, 1981 | San José State 27, Utah State 24 | Box score |
| Oct 24, 1981 | South Carolina 31, 3North Carolina 13upset | Box score |
| Oct 24, 1981 | 5USC 14, Notre Dame 7 | Box score |
| Oct 24, 1981 | Southern Illinois 41, Louisiana 0 | Box score |
| Oct 24, 1981 | Temple 24, Cincinnati 13 | Box score |
| Oct 24, 1981 | Tennessee 28, Memphis 9 | Box score |
| Oct 24, 1981 | 10Texas 9, 8SMU 7upset | Box score |
| Oct 24, 1981 | Texas A&M 51, Rice 26 | Box score |
| Oct 24, 1981 | Texas–Arlington 7, North Texas 6 | Box score |
| Oct 24, 1981 | UTEP 35, Colorado State 29 | Box score |
| Oct 24, 1981 | Tulane 27, Georgia Tech 10 | Box score |
| Oct 24, 1981 | Tulsa 52, Wichita State 21 | Box score |
| Oct 24, 1981 | UCLA 34, California 6 | Box score |
| Oct 24, 1981 | Utah 69, UNLV 28 | Box score |
| Oct 24, 1981 | Vanderbilt 27, Ole Miss 23upset | Box score |
| Oct 24, 1981 | VMI 20, Marshall 16 | Box score |
| Oct 24, 1981 | Virginia Tech 34, App State 12 | Box score |
| Oct 24, 1981 | Wake Forest 24, Virginia 21 | Box score |
| Oct 24, 1981 | Washington 14, Texas Tech 7 | Box score |
| Oct 24, 1981 | 16Washington State 34, Arizona 19 | Box score |
| Oct 24, 1981 | Western Carolina 24, Chattanooga 10upset | Box score |
| Oct 24, 1981 | Western Michigan 14, Ball State 3 | Box score |
| Oct 24, 1981 | Wyoming 33, 13BYU 20upset | Box score |
| Oct 24, 1981 | Yale 24, Pennsylvania 3 | Box score |