| Oct 17, 1981 | 15Alabama 38, Tennessee 19 | Box score |
| Oct 17, 1981 | Arizona 18, Oregon 14 | Box score |
| Oct 17, 1981 | 20Arizona State 45, California 17 | Box score |
| Oct 17, 1981 | Arkansas 42, 1Texas 11upset | Box score |
| Oct 17, 1981 | Army 34, Princeton 0 | Box score |
| Oct 17, 1981 | Auburn 31, Georgia Tech 7 | Box score |
| Oct 17, 1981 | Baylor 19, Texas A&M 17 | Box score |
| Oct 17, 1981 | Bowling Green 17, Northern Illinois 10 | Box score |
| Oct 17, 1981 | 17BYU 27, San Diego State 7 | Box score |
| Oct 17, 1981 | Chattanooga 3, Arkansas State 2 | Box score |
| Oct 17, 1981 | Cincinnati 27, Richmond 18 | Box score |
| Oct 17, 1981 | 6Clemson 38, Duke 10 | Box score |
| Oct 17, 1981 | Colorado 11, Oklahoma State 10 | Box score |
| Oct 17, 1981 | Cornell 14, Brown 9upset | Box score |
| Oct 17, 1981 | Dartmouth 24, Harvard 10 | Box score |
| Oct 17, 1981 | East Carolina 35, Louisiana 31 | Box score |
| Oct 17, 1981 | Florida 49, Ole Miss 3 | Box score |
| Oct 17, 1981 | 9Georgia 53, Vanderbilt 21 | Box score |
| Oct 17, 1981 | Hawai’i 23, New Mexico 13 | Box score |
| Oct 17, 1981 | Indiana 17, Minnesota 16 | Box score |
| Oct 17, 1981 | 12Iowa 9, 5Michigan 7upset | Box score |
| Oct 17, 1981 | Iowa State 34, 8Missouri 13upset | Box score |
| Oct 17, 1981 | Kent State 17, Ball State 7upset | Box score |
| Oct 17, 1981 | LSU 24, Kentucky 10 | Box score |
| Oct 17, 1981 | Louisiana Tech 16, Lamar 7 | Box score |
| Oct 17, 1981 | Maryland 45, Wake Forest 33 | Box score |
| Oct 17, 1981 | McNeese 41, UL Monroe 25 | Box score |
| Oct 17, 1981 | Miami (OH) 20, Western Michigan 19 | Box score |
| Oct 17, 1981 | Michigan State 33, 14Wisconsin 14upset | Box score |
| Oct 17, 1981 | 16Mississippi State 14, 13Miami 10upset | Box score |
| Oct 17, 1981 | Navy 25, Boston College 10 | Box score |
| Oct 17, 1981 | 19Nebraska 49, Kansas State 3 | Box score |
| Oct 17, 1981 | New Mexico State 20, Illinois State 10 | Box score |
| Oct 17, 1981 | 4North Carolina 21, NC State 10 | Box score |
| Oct 17, 1981 | Ohio 29, Eastern Michigan 7 | Box score |
| Oct 17, 1981 | Ohio State 34, Illinois 27 | Box score |
| Oct 17, 1981 | Oklahoma 45, Kansas 7 | Box score |
| Oct 17, 1981 | Pacific 17, Long Beach State 10upset | Box score |
| Oct 17, 1981 | 2Penn State 41, Syracuse 16 | Box score |
| Oct 17, 1981 | 3Pittsburgh 42, 11Florida State 14 | Box score |
| Oct 17, 1981 | Purdue 35, Northwestern 0 | Box score |
| Oct 17, 1981 | Rice 30, Texas Tech 23 | Box score |
| Oct 17, 1981 | San José State 45, Cal State Fullerton 23 | Box score |
| Oct 17, 1981 | South Carolina 21, Virginia 3 | Box score |
| Oct 17, 1981 | 7USC 25, Stanford 17 | Box score |
| Oct 17, 1981 | Southern Illinois 24, Fresno State 18 | Box score |
| Oct 17, 1981 | 10SMU 38, Houston 22 | Box score |
| Oct 17, 1981 | Southern Miss 10, Memphis 0 | Box score |
| Oct 17, 1981 | Temple 24, Rutgers 12upset | Box score |
| Oct 17, 1981 | Toledo 17, Central Michigan 3 | Box score |
| Oct 17, 1981 | Tulane 31, Air Force 13 | Box score |
| Oct 17, 1981 | Tulsa 20, Indiana State 19 | Box score |
| Oct 17, 1981 | 18Washington State 17, UCLA 17 | Box score |
| Oct 17, 1981 | Utah 24, Colorado State 13 | Box score |
| Oct 17, 1981 | TCU 13, Utah State 13 | Box score |
| Oct 17, 1981 | App State 14, VMI 14 | Box score |
| Oct 17, 1981 | Washington 56, Oregon State 17 | Box score |
| Oct 17, 1981 | West Texas 23, Wichita State 17 | Box score |
| Oct 17, 1981 | West Virginia 27, Virginia Tech 6 | Box score |
| Oct 17, 1981 | William & Mary 38, Marshall 7 | Box score |
| Oct 17, 1981 | Wyoming 63, UTEP 12 | Box score |
| Oct 17, 1981 | Yale 48, Columbia 17 | Box score |